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NCT Number: NCT07273526

Adrenaline V/s Dopamine in Fuid Refractory Septic Shock

This study compares the efficacy of two drugs i.e Adrenaline and dopamine in fluid refractory type of septic shock which is a dreadful medical condition especially in children. The efficacy will be checked based on heart rate , GCS, capillary refill time , palpable pripheral pulse , urine output and systolic blood pressure.

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Key information

Conditions

Fluid Refractory Septic Shock Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Septic Shock Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

1 month–12 month

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Children Hospital and The Institute of Child Health Faisalabad

Faisalābad, Punjab Province, 38000, Pakistan

Location status: Recruiting

Location contact

Zahid Mahmood Dr, MBBS, FCPS

CONTACT

[email protected]

03336507982

About this study

This is a randomized control trial in which children / patients diagnosed with Fluid refractory Septic shock will be provided with one of the two drugs ina randomzied way and their efficacy will be assesed on the basis of correction of various parameters at various points of time.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.

-

Exclusion criteria

  • Patients with
  • cardiopumonary Bypass during last 5 days
  • Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
  • neuromuscular discorder
  • Metabolic disorders
  • Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation

Treatment and study plan

Adrenaline

Drug

The adrenaline will be given as a vasoconstrictor in the dose of 0.1-0.3ug/kg/min to the patients in group A when diagnosed with fluid refractory septic shock

Dopamine

Drug

The drug dopamine will be adminitered in dose of 10-20ug/kg/min to the patients of group B when diagnosed with fluid refractory septic shock.

Primary outcomes

  1. Blood Pressure

    Time frame: 6 hours

    The blood pressure of the patients will be meaures after administration of each drug at 20 mins and 6 hours.

  2. Pulse

    Time frame: 6 hours

    The pulse will be compared after adminitration of both drugs at 20 mins and 6 hours

  3. Capillary Refill Time

    Time frame: 6 Hours

    Capillary Refill time will be assessed after administration of each drug at 20 mins and 6 hours

  4. Urine output

    Time frame: 6 hours

    Urine output will be calculated from the time of administration of each drug at 20mins and 6 hours and comapred.

  5. GCS

    Time frame: 6 hours

    Glascow Comma Scale (GCS) will be asses at 20 mins and 6 hours after administration of each drug

Secondary outcomes

  1. SOFA ( Sequential Organ Failure Assesment)

    Time frame: 6 Hours

    SOFA ( Sequential Organ Failure Assesment) score will be calculated afte adminitration of each drug at 20mins and 6 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Hafiz Muhammad Abdullah Dr, MBBS

CONTACT

[email protected]

03440846288

Sponsors and collaborators

Lead sponsor

Laiba Qamar

Other

Registry information

Official study title

Comparison of the Efficacy of Renaline and Dopamine in the Treatment of Fluid Refractory Septic Shock in Children

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Dec 9, 2025
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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