Adrenaline During Resuscitation From Pulseless Electrical Activity

This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

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Key information

Conditions

Heart Arrest Cardiovascular Diseases Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

St Olavs Hospital, Trondheim, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Treatment and study plan

Primary outcomes

QRS frequency

Time frame: Every 3 minutes from start till end of cardiopulmonary resuscitation

Measurement of RR intervals in milliseconds.
QRS width

Time frame: Every 3 minutes from start till end of cardiopulmonary resuscitation

Measurement of the width of QRS complexes in milliseconds
Changes of clinical states

Time frame: Every 3 minutes from start till end of cardiopulmonary resuscitation

changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest.

Sponsors and collaborators

Lead sponsor

St. Olavs Hospital

Other

Collaborators

Norwegian University of Science and Technology
University of Pennsylvania

Registry information

Important dates

Study start: 2019
Primary completion: 2023
Study completion: 2023
First posted: Nov 4, 2019
Registry last updated: Sep 5, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed