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Completed

NCT Number: NCT03276650

Admission of Adult-onset Still Disease Patients in the ICU

Since its first description in 1971, diagnosing adult-onset Still's disease (AOSD), a rare multisystemic disorder considered as a multigenic autoinflammatory syndrome, remains challenging. Rarely, AOSD may present severe systemic manifestations and require intensive care. The main purpose of the Stil ICU study is to make the first description of the epidemiology of critically ill AOSD patients. The investigators will use a retrospective cohort study design with dual recruitment strategies: (1) via the AOSD referral centres network and (2) via a French academic medical ICU network.

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Key information

Conditions

Adult-Onset Still Disease Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Critical Illness Critically Ill Disease Attributes Immune System Diseases Joint Diseases Musculoskeletal Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Rheumatic Diseases Skin and Connective Tissue Diseases Still's Disease, Adult-Onset

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU

Nancy, 54000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • AOSD (history of newly diagnosed)
  • ICU admission between January 2001 and June 2017

Exclusion criteria

  • adults under protection
  • admission in step-down unit

Treatment and study plan

Data Collection

Other

biological, administrative, clinical, outcome date

Primary outcomes

  1. number of patients

    Time frame: At inclusion

    Number of patients fulfilling the inclusion criteria

Secondary outcomes

  1. APACHE II

    Time frame: 24hour after ICU admission

    Acute Physiologic Assessment and Chronic Health Evaluation II

  2. Mortality

    Time frame: through study completion, maximum 17,5 years after admission

    Kaplan Meier

  3. Number of rehospitalisation in ICU

    Time frame: through study completion, maximum 17,5 years after admission

    need for critical care after the first hospitalisation in ICU

  4. number of hospitalisation in internal medicine ward

    Time frame: through study completion, maximum 17,5 years after admission

    number of hospitalisation in internal medicine ward after the first ICU stay

  5. recurrent relapses

    Time frame: through study completion, maximum 17,5 years after admission

    number of recurrent flares after the first hospitalisation in ICU

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Admission of Adult-onset Still Disease Patients in the ICU: a French Retrospective Multicentric Study

Acronym: Still-ICU

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Sep 8, 2017
Registry last updated
Sep 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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