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Completed

NCT Number: NCT00460044

ADMA and Mechanical Ventilation in Preterm Infants

The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth.

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Key information

Conditions

Premature Birth Female Urogenital Diseases and Pregnancy Complications Obstetric Labor Complications Obstetric Labor, Premature Pregnancy Complications Urogenital Diseases

Age range

Up to 32 week

Sex eligibility

All sexes

Study type

Observational

About this study

Nitric oxide (NO) plays an important role in the normal development and maturation of the lungs. In addition, NO is an important mediator of vascular smooth muscle relaxation, ventilation perfusion matching, neurotransmission and host defence and bacteriostasis. Asymmetric dimethylarginine (ADMA) is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO. Preterm infants have increased concentrations of ADMA. Therefore, inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gestational age < 32 weeks
  • Birth weight < 1500 gram
  • Written informed consent of parents

Exclusion criteria

  • Congenital abnormalities
  • Chromosomal abnormalities

Sponsors and collaborators

Lead sponsor

Amsterdam UMC, location VUmc

Other

Registry information

Official study title

Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants

Important dates

Study start
2002
Study completion
2003
First posted
Apr 13, 2007
Registry last updated
Apr 13, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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