Adipose-derived Stem Cells (ADSCs) for Knee Osteoarthritis

Inclusion criteria

• Aged 40-80 years (inclusive)
• Kellgren-Lawrence grading I-III, as determined by American College of Rheumatology (ACR) criteria for osteoarthritis of the knee
• Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score of 7-17 in the study knee even if treated with chronic doses of non steroidal anti-inflammatory drugs
• Having provided informed consent

Exclusion criteria

• With previous surgery of articular fracture, ligament reconstruction, meniscal reconstruction, and knee arthroplasty on the target knee joint
• With previous intra-articular intervention on the target knee joint within past 3 months (e.g. steroid, anaesthetic, sodium hyaluronate)
• Known or suspected infection of the target knee joint
• Ascertained hypersensitivity to any component used in the study
• Administered with systemic anti-inflammatory drugs (e.g. non-steroidal anti-inflammatory drug or steroid ) or topical anti-inflammatory drugs on target knee within 7 days prior to administration in the study
• With serious prior or ongoing medical conditions (e.g. concomitant illness such as cardiovascular (e.g. New York Heart Association grade III or IV), hepatic (e.g. Child-Pugh Class C), psychiatric condition, alcoholism, drug abuse), medical history, physical findings, , or laboratory abnormality that in the investigators' opinion could interfere with the results of the trial or adversely affect the safety of the patient
• With any evidence of malignant disease with life expectancy of less than 1 year
• Pregnant or lactating women or planning to be pregnant during the study period
• With body mass index (BMI) greater or equal to 35 kg/m2
• With joint diseases except knee osteoarthritis considered by investigator not eligible to enter the study
• With known history of human immunodeficiency virus (HIV) infection.
• Judged to be not applicable to this study by investigator such as difficulty of follow-up observation
• With any other serious diseases/medical history considered by the investigator not in the condition to enter the trial
• Having participated other investigational study within 4 weeks of entering this study
• With known history of claustrophobia
• Having any existing active/inactive implanted medical devices, such as cardiac pacemaker, cochlear, intracranial vascular clips or neurostimulator, etc...
• Having any existing metallic intraocular foreign body