Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

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Key information

Conditions

Obesity, Metabolically Benign Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

4 year–18 year

Sex eligibility

All sexes

Study type

Observational

About this study

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

obese children (BMI> 95th percentile)

Exclusion criteria

obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Treatment and study plan

MetS+

Other

Data processing from Patient Medical Files

MetS-

Other

Data processing from Patient Medical Files

Primary outcomes

Defining obesity in the pediatric population

Time frame: Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.

Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph.
Leptin changes in the obese children with metabolic syndrome

Time frame: Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml.

Evaluating leptin in the obese group with metabolic syndrome
Adiponectin changes in the obese children with metabolic syndrome

Time frame: Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values.

Evaluating adiponectin in the obese group with metabolic syndrome
Assessing cardiovascular risk in the obese children with metabolic syndrome

Time frame: hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l

Evaluating hsCRP in the obese group with metabolic syndrome

Sponsors and collaborators

Lead sponsor

Alexandru Florin Rogobete

Other

Collaborators

University of Medicine and Pharmacy "Victor Babes" Timisoara

Registry information

Acronym: ChildObes

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Nov 28, 2017
Registry last updated: Nov 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed