Adiponectin and Ethnic Differences in Insulin Resistance

The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

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Key information

Conditions

Insulin Resistance Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Nutritional and Metabolic Diseases Type 2 Diabetes

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Colorado Anschutz Medical Center

Aurora, Colorado, 80045, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18-60 years of age
BMI 20.0-34.9 m/kg2
Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

Exclusion criteria

pregnancy
breastfeeding
diabetes mellitus
blood pressure > 160/100 mmHg
creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
liver function tests > 3x upper limit of normal (ULN)
h/o heart failure
h/o eating disorder

Treatment and study plan

None- observational study

Other

Primary outcomes

total adiponectin concentration

Time frame: measured once during second study visit, in fasting condition

Secondary outcomes

Insulin sensitivity

Time frame: Measured once, during second study visit.

Calculated from insulin and glucose values obtained during IV glucose tolerance test.

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Registry information

Official study title

Adiponectin as an Independent Determinant of Ethnic Differences in Insulin Resistance

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: Apr 15, 2013
Registry last updated: Apr 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed