Adiponectin and Circulating Progenitor Cells (CPC) Function

Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1

Primary location

University of Leipzig, Heart Center

Leipzig, 04289, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

≤ 75 years of age
stable coronary artery disease
preserved left ventricular function
physical work capacity of ≥ 50
successful elective percutaneous coronary intervention at study begin

Exclusion criteria

diabetes mellitus
hypercholesterolemia
untreated hypertension
smoking
myocardial infarction within the last 4 weeks
significant stenosis of the left main coronary artery

Treatment and study plan

Exercise training

Other

4 weeks supervised physical exercise training

Primary outcomes

migratory capacity of endothelial progenitor cells towards an SDF-1 gradient

Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

University of Leipzig

Other

Collaborators

German Research Foundation
Heart Center Leipzig - University Hospital

Registry information

Official study title

Adiponectin Promotes the Migration of Circulating Progenitor Cells Through p38-mediated Induction of the CXCR4 Receptor

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: Jan 10, 2011
Registry last updated: Jun 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed