Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients

Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level

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Key information

Conditions

NAFLD Digestive System Diseases Fatty Liver Liver Diseases NASH - Nonalcoholic Steatohepatitis Non-alcoholic Fatty Liver Disease

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

El Sahel teaching hospital

Cairo, Shobra, 11311, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Egyptian patients confirmed NAFLD diagnosis diabetic

Exclusion criteria

Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease

Treatment and study plan

DNA extraction

Genetic

investigation of DNA polymorphism in patients suffering from NAFLD

Primary outcomes

investigate adipokine dna polymorphism

Time frame: 1 months

to investigate adipokine gene polymorphism associated with prognosis of NAFLD patients
correlations

Time frame: 1 month

to correlate between gene polymorphism and glycated hemoglobin, liver enzyme and obesity

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Collaborators

El-Sahel Teaching Hospital

Registry information

Official study title

Genetic Variations in Adipokine to Improve Risk Prediction for NAFLD and Its Progression to NASH in Egyptian Patients

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Sep 24, 2020
Registry last updated: Sep 24, 2020

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed