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Completed

NCT Number: NCT07012083

Adherence to Anti-rabies Post-exposure Prophylactic Protocols

This study aims to investigate physicians' adherence to Advisory Committee on Immunization Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Medicine Tanta university

Tanta, Gharbia Governorate, Egypt

About this study

There is no known effective treatment for rabies, and virtually all cases are fatal. Although the prognosis is poor in patients who develop rabies, the disease is usually preventable with proper wound care and post-exposure prophylaxis. Following a thorough risk assessment, the decision to initiate rabies post-exposure prophylaxis should be made. The risk assessment should consider the type of exposure, local rabies epidemiology in animals, vaccination history of the animal, circumstances of the exposure incident, and the availability of the animal for observation or rabies testing .

The World Health Organization (WHO) and the Advisory Committee on Immunization Practices (ACIP) have adopted guidelines for starting post-exposure prophylaxis (PEP) against rabies. The decision to start Anti-Rabies PEP is usually made in primary health care units or emergency departments .

Lack of adherence to these guidelines might result in unnecessary costs and medical risks, such as injection site reactions and systemic hypersensitivity reactions . This malpractice of inappropriate anti-rabies PEP prescription is not uncommon.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physicians who treat patients with animal bites potentially requiring post-exposure anti-rabies prophylaxis. The sample will include emergency physicians, general practice or family physicians, and surgeons of both sexes, with varying degrees of experience and post-graduate clinical training.

Exclusion criteria

  • Incomplete record filling

Treatment and study plan

Survey

Other

This cross-sectional survey study will be conducted on a consecutive sample of physicians who treat patients with animal bites potentially requiring post-exposure anti-rabies prophylaxis. The sample will include emergency physicians, general practice or family physicians, and surgeons of both sexes, with varying degrees of experience and post-graduate clinical training.

All participants will consent to submit an anonymous Google Form-based questionnaire. The designed questionnaire will include introductory personal, academic, and work experience data about the physicians as gender, age, specialty, workplace, highest achieved medical-academic or training degree, and number of years of postgraduate clinical work experience. Candidates will be asked to reflect on their pre and postgraduate education/training quality and their confidence level in prescribing anti-rabies post-exposure prophylaxis treatment. (as a linear scale).

Primary outcomes

  1. Adherence to Anti-rabies PEP Guidelines

    Time frame: 6 months

    This study aims to investigate physicians' adherence to the Advisory Committee on Immunization.

    Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt. This will be through a score given for the correct response to the case-based questionnaire. This questionnaire include 10 case-based scenarios where anti-rabies post-exposure prophylaxis may or may not be indicated as per ACIP guidelines. True response will be scored 1, wrong response will be scored 0 with maximum total score of 10. Higher score reflects better adherence to guidelines recommendations & vice versa.

Secondary outcomes

  1. Health & Economic burden of such malpractice

    Time frame: 9 months

    This study attempts to evaluate the possible economic burden of this expected departure from the standard of care by examining doctors' compliance with appropriate prescription of anti-rabies post-exposure prophylaxis. Economic burden will be calculated by incorporating total odds ratio of inappropriate prescription of anti-rabies vaccine with or without human rabies immunoglobulin , cost of each dose of them to get a rough estimate of the expected cost rising from inappropriate prescription of theses drugs when they are not indicated.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Egyptian Doctors' Adherence to Anti-rabies Post-exposure Prophylactic Protocols; A Survey Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 10, 2025
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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