Adherence, Efficacy and Safety of an Insulin Protocol in the Critically Ill: A Prospective Observational Study

There is a growing body of evidence in the literature regarding the adverse effects of hyperglycemia in critically ill patients. To target and maintain better blood glucose regulation we implemented an insulin protocol with target blood glucose levels between 81-110 mg/dL.

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Key information

Conditions

Critically Ill Patients

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University Hospital Ghent

Ghent, 9000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Surgical or medical critically ill patients
An expected ICU-stay of more than 72 hours
Age > 16 years
Need for insulin therapy
Patients must have an arterial line

Exclusion criteria

Patients who did not respond to the inclusion criteria
Patients with diabetic ketoacidosis
Cardiac surgical patients
Patients transferred from other hospitals
Other study enrollment

Treatment and study plan

to implement an insulin protocol with target blood glucose levels between 81-110 mg/dL.

Drug

Primary outcomes

To evaluate compliance, efficacy and safety of an insulin protocol, with target glycemia between 81-110 mg/dL in critically ill patients

Secondary outcomes

To determine potential factors associated with blood glucose control

Sponsors and collaborators

Lead sponsor

University Hospital, Ghent

Other

Registry information

Important dates

Study start: 2002
Study completion: 2002
First posted: Feb 8, 2006
Registry last updated: Dec 28, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed