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Completed

NCT Number: NCT01470391

Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement

The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.

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Key information

Conditions

Total Knee Arthroplasty Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anaesthesia, Copenhagen University Hospital, Frederiksberg

Frederiksberg, 2000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 1-3
  • BMI > 18 og < 40
  • total knee arthroplasty in spinal anesthesia

Exclusion criteria

  • Can not cooperate to the exam
  • Do not speak or understand Danish
  • Drug allergy
  • Alcohol or drug abuse
  • Daily consumption of strong opioids
  • Rheumatoid arthritis
  • Intake of glucocorticoids
  • Effect of spinal anesthesia stopped prior to performing the regional block

Treatment and study plan

Adductor-Canal-Blockade

Procedure

US-guided Adductor-Canal-Blockade with Ropivacaine

Femoral Nerve Block

Procedure

US-guided Femoral Nerve Block with Ropivacaine

Primary outcomes

  1. The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block

    Time frame: 24 h postoperatively

Secondary outcomes

  1. The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block

    Time frame: 24 h postoperatively

  2. Pain during flexion of the knee

    Time frame: 2-24 hours

    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

  3. Pain at rest

    Time frame: 2-24 hours

    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

  4. Total morphine consumption

    Time frame: 0-24 hours

  5. Postoperative nausea

    Time frame: 2-24 hours

  6. Postoperative vomiting

    Time frame: 0-24 hours

  7. Sedation

    Time frame: 2-24 hours

  8. Zofran consumption

    Time frame: 0-24 hours

    Number of patients recieveing zofran postoperatively

  9. The difference in mobilization between the groups

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Official study title

"A Comparison of the Efficacy of the Adductor-Canal-Blockade Versus the Femoral Nerve Block on Muscle Strength, Pain and Mobilization After Total Knee Arthroplasty: a Randomized Study

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Nov 11, 2011
Registry last updated
Dec 18, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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