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NCT Number: NCT06986590

Addressing Hypertension Care in Africa Program

The ADHINCRA Program is a bundle of multilevel evidence-based interventions that address multiple predictors of controlled hypertension, including patient-, provider-, and health system-level factors. The successful implementation of the ADHINCRA program will provide a rigorous and scalable model for improving hypertension control in Africa, which would ultimately reduce the risk of cardiovascular disease, stroke and kidney disease.

Recruiting

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Key information

Conditions

Hypertension Cardiovascular Diseases High Blood Pressure Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dominase SDA Hospital, Bekwai, Ashanti Region, Ghana

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 -70 years.
  • Diagnosis of hypertension and elevated systolic blood pressure measure (≥140 mmHg) on the most recent clinic visit without a diabetes diagnosis.
  • Hypertension treatment naive or on monotherapy.
  • Receives primary care at one of the participating sites.
  • Willing and able to provide informed consent in English, Twi, Dagbani, Ewe, Hausa, or Yoruba.
  • Owns a smartphone (Android or iOS).

Exclusion criteria

  • Age <18 years or >70 years.
  • Severely elevated BP (≥180/110mmHg).
  • Diagnosis of stroke, coronary artery disease, or kidney disease.
  • Diagnosis of end-stage renal disease (ESRD) treated with dialysis.
  • Serious medical condition which either limits life expectancy or requires active management (e.g., cancer).
  • Cognitive impairment or other conditions preventing study participation
  • Pregnant or currently nursing a child
  • Unwilling to provide informed consent

Treatment and study plan

ADHINCRA Program

Behavioral

The ADHINCRA Program is a nurse-led intervention that includes the use of home blood pressure monitoring, a mobile health app, lifestyle counselling, and a simplified hypertension treatment protocol to achieve blood pressure control among people diagnosed with hypertension.

Primary outcomes

  1. Number of participants with systolic blood pressure <140 mmHg

    Time frame: Baseline and 12 months post-randomization

    Blood pressure control among participants defined as systolic blood pressure <140 mmHg

Secondary outcomes

  1. Number of participants with diastolic blood pressure <90 mmHg

    Time frame: Baseline, 12 months, 24 months post-randomization

    Blood pressure control as assessed by diastolic blood pressure <90mmHg

  2. Medication adherence as assessed by Hill-Bone Medication Adherence Scale

    Time frame: Baseline, 12 months, 24 months post-randomization

    Adherence to medications prescribed per the ADHINCRA Program treatment protocol. The total score ranges from 14 - 56. Higher score is better adherence.

  3. Percentage of sites that adopt and maintain the intervention as assessed by the Pragmatic Robust Implementation and Sustainability Model

    Time frame: Baseline, 12 months, 24 months post-randomization

    Use the Pragmatic Robust Implementation and Sustainability Model (PRISM) to evaluate the reach, adoption, maintenance of the ADHINCRA Program

  4. Difference in cost of intervention compared to usual care as assessed by the Pragmatic Robust Implementation and Sustainability Model

    Time frame: Baseline, 12 months, 24 months post-randomization

    Use the Pragmatic Robust Implementation and Sustainability Model (PRISM) to evaluate the cost-effectiveness of the ADHINCRA Program

Study contacts

Contact information is provided by the study sponsor or research team.

Research Program Manager

CONTACT

[email protected]

Yvonne Commodore-Mensah, PhD, MHS, RN

CONTACT

[email protected]

410-614-1519

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Addressing Hypertension Care in Africa (ADHINCRA) Program

Acronym: ADHINCRA

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 23, 2025
Registry last updated
Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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