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NCT Number: NCT04918108

Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Multicenter Cohort Study) III

Anatomopathological classifications have been well identified in aortic dissection with important therapeutic implications. The authors evaluated the inflammatory response in patients with aortic dissection (AD) and assessed the presence of distinct inflammatory subphenotypes within this disease.

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Key information

Conditions

Aortic Dissection Acute Aortic Syndrome Aneurysm Aortic Diseases Cardiovascular Diseases Dissection, Blood Vessel Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The first affiliated hospital of nanjing medical university

Nanjing, Jiangsu, 210029, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • acute type Aortic dissection;

Exclusion criteria

  • Iatrogenic aortic dissection OR traumatic aortic dissection
  • Patients with hematological diseases, infectious diseases, malignant tumors, immune system diseases, or severe liver diseases.
  • Preoperative use of mechanical ventilation, blood transfusion, renal replacement therapy, extracorporeal membrane oxygenation, or intra-aortic balloon pump during the current admission.

Treatment and study plan

inflammatory response

Biological

laboratory data (leukocyte, neutrophils, monocyte, lymphocytes, platelet, fibrinogen, D-dimer, neutrophils-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio)

Primary outcomes

  1. 30-day mortality

    Time frame: 30 days after surgery

    any cause death within 30 days of surgery

Secondary outcomes

  1. ICU mortality

    Time frame: 7 days after surgery

    any cause death within ICU

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Collaborators

  • Beijing Anzhen Hospital
  • First Affiliated Hospital of Shantou University Medical College
  • Nanjing First Hospital, Nanjing Medical University
  • Shanghai East Hospital of Tongji University
  • TEDA International Cardiovascular Hospital
  • The Affiliated Hospital of Qingdao University
  • The First Affiliated Hospital of Bengbu Medical University
  • The First Affiliated Hospital of Guangzhou Medical University
  • The First Affiliated Hospital with Nanjing Medical University
  • Tianjin Chest Hospital, Tianjin Medical University
  • Xiamen Cardiovascular Hospital
  • Xiangya Hospital of Central South University

Registry information

Official study title

Inflammatory Response and Anti-inflammatory Action for Aortopathy & Arteriopathy (5A-Plan): A Multicenter Cohort Study

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jun 8, 2021
Registry last updated
Nov 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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