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NCT Number: NCT07573683

Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals

This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension. Participants will be randomly assigned to an intervention group (aerobic exercise plus coherent breathing) or a control group (aerobic exercise only) and will undergo a 4-week program with 5 sessions per week.

Cardiopulmonary parameters-including blood pressure, heart rate, respiratory rate, and rate pressure product-will be measured, and quality of life will be assessed using the MINICHAL questionnaire at baseline, 2 weeks, and post-intervention. Data will be analyzed using SPSS version 21.0.

The study aims to determine whether coherent breathing provides additional benefits, offering a cost-effective, non-pharmacological strategy for hypertension management in low-resource settings.

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Key information

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Foundation University Islamabad

Islamabad, Pakistan

Location status: Recruiting

Location contact

Syeda Sumaira Batool, MSPT-CPT

CONTACT

[email protected]

03328868680

About this study

Hypertension, also known as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure. A normal reading is less than 120 millimeters of mercury over less than 80 millimeters of mercury. Hypertension is a prevalent condition affecting approximately 1.28 billion individuals globally, with a significant burden observed in low- and middle-income countries such as Pakistan. Stage 1 hypertension is defined by a systolic blood pressure (SBP) between 130-139 mmHg or diastolic blood pressure (DBP) between 80-89 mmHg. High blood pressure causes no signs or symptoms, which is why healthcare providers call it a "silent killer." Non-pharmacological interventions, including aerobic exercise and breathing techniques, have shown promise in improving cardiopulmonary function and quality of life.

Coherent breathing is a controlled breathing technique that involves inhaling and exhaling at a steady, slow pace-typically around five to six breaths per minute, with each inhale and exhale lasting about six seconds. This study aims to evaluate the additional effects of coherent breathing techniques when combined with aerobic exercise, compared to aerobic exercise alone. A randomized controlled trial design will be employed. The study will be conducted over a period of 1 year at Foundation University College of Physical Therapy and Fauji Foundation Hospital Rawalpindi. Ethical approval will be obtained from ERC FUMC and IRC, and the trial will be registered with CBRC and the clinical trial registry. Data will be analyzed using SPSS version 21.0.

This study will fill a critical gap in the literature by assessing the additive benefits of coherent breathing in hypertension management. The findings may support cost-effective, non-pharmacological strategies in low-resource settings, contributing to improved public health outcomes

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both male and female genders.
  • Adults aged 30-65 years.
  • Patients diagnosed with stage 1 hypertension 130-139/80-89mm Hg according to ACC/AHA 2017 guidelines.
  • Mild to moderate physical activity level on IPAQ questionnaire.
  • Individuals able to understand and follow the instructions.

Exclusion criteria

  • Diagnosed uncontrolled hypertensive patients.
  • Unstable angina, MI, heart failure, advanced CAD patients, COPD, Asthma.
  • Severe neurological, musculoskeletal or gynecological conditions which limit participation in the study.
  • Recent history of fracture.

Treatment and study plan

Coherent Breathing.

Other

Coherent breathing technique involve consciously reducing the breathing rate, typically to fewer than 10 breaths per minute, often around 6 breaths per minute. Coherent breathing is performed for 10 minutes.

Aerobic Exercises involving brisk walking, warm up, stepper, static cycling, cool down for a period of 30 min.

aerobic exercises

Other

Aerobic Exercises involving brisk walking, warm up, stepper, static cycling, cool down for a periof of 30 min.

Primary outcomes

  1. Heart Rate (beats per minute)

    Time frame: 04 weeks

    Measured using calibrated digital monitor after 5 minutes rest at baseline and post-intervention.

  2. Systolic Blood Pressure (mmHg)

    Time frame: 04 weeks

    Measured using standardized sphygmomanometer at baseline and post-intervention.

  3. Diastolic Blood Pressure (mmHg)

    Time frame: 04 weeks

    Measured using standardized sphygmomanometer at baseline and post-intervention.

  4. Peripheral Oxygen Saturation (SpO₂, %)

    Time frame: 04 weeks

    Measured using pulse oximeter under resting conditions at baseline and post-intervention.

  5. Respiratory Rate (breaths/minute)

    Time frame: 04 weeks

    Measured by direct observation at baseline and post-intervention.

  6. Rate Pressure Product (HR × SBP)

    Time frame: 04 weeks

    Calculated from heart rate and systolic blood pressure at baseline and post-intervention as an index of myocardial workload.

Study contacts

Contact information is provided by the study sponsor or research team.

Kainat Zahra, MSPT-CPPT

CONTACT

[email protected]

03367343005

Syeda Sumaira Batool, MSPT-CPT

CONTACT

[email protected]

03328868680

Sponsors and collaborators

Lead sponsor

Foundation University Islamabad

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 7, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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