Adderall XR and Processing Speed in Multiple Sclerosis (MS)

Inclusion criteria

• - Males/Females who are ≥ 18 years old and ≤ 59 years old
• Relapsing Remitting, Secondary Progressive or Primary Progressive MS, as per revised McDonald's Criteria
• Have not received corticosteroids in last thirty days or a relapse in the last ninety days
• An Expanded Disability Status Scale (EDSS) of ≤ 6.5
• If female, must neither be pregnant nor breast-feeding

Exclusion criteria

• - Have evidence of other medical cause(s) of cognitive impairment
• Have evidence of major depression as determined by a positive Beck Depression Index-Fast screen ≥ 13and/or by clinician interview or evidence of severe fatigue with a Fatigue Severity Scale ≥ 5.
• Have demonstrated a hypersensitivity to amphetamines in the past
• Have uncontrolled or labile hypertension (> 135/85 mm Hg, treated or untreated)
• Have a history of structural heart disease, including atherosclerosis or angina
• Have a diagnosis of bipolar disorder or a history of a psychotic episode
• The following medications are not permitted to be used within 14 days the study

• Monoamine Oxidase Inhibitors
• Sympathomimetics or methadone
• Antipsychotic agents
• Modafinil
• The following medications are permitted if the dose has been stable for ≥ 28 days

• Short acting benzodiazepines, qhs administration only
• Anticonvulsants, including gabapentin and pregabalin
• Bupropion
• Tricyclic Antidepressants
• Anti-spasmodics such as baclofen or tizanidine
• Anticholinergic medication
• Selective serotonin(-norepinephrine) reuptake inhibitors