University of Colorado
Aurora, Colorado, 80045, United States
Location status: Recruiting
Location contact
Drew Kern, MD
PRINCIPAL_INVESTIGATOR
Pamela David Gerecht, PhD
CONTACT
Recruiting
NCT Number: NCT06296810
Adaptive DBS to Offset STN Dysregulation During Exercise in PD
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
20 year–70 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.
-
Exclusion criteria
Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Treatment and study plan
aDBS
Deviceadaptive deep brain stimulation
Primary outcomes
-
identification of L-beta frequency peak power
Time frame: 4 weeks
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University of Colorado, Denver
Other
Registry information
Official study title
Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease
Important dates
- Study start
- 2024
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Mar 6, 2024
- Registry last updated
- Mar 17, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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