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NCT Number: NCT07754656

Adapted Cardiopulmonary Resuscitation Study

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.

Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .

Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.

The intervention group will receive a modified treatment including:

* thorax compression via mechanical device (LUCAS 3) * head up Cardiopulmonary Resuscitation (cpr) * use of an impendance threshold device (ITD) module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

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Key information

Conditions

Cardiac Arrest (CA) Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age> 18 years
  • time of resuscitation <21 minutes when enrollement starts

Exclusion criteria

  • obvious pregnancy
  • contraindications for the use of Lucas 3
  • time of resuscitation >21 minutes and etCO2 <15 mmHg upon arrival of the emergency physician on scene
  • Exclusion from the emergency physician from study due to futility.

Treatment and study plan

aCPR algorithm

Procedure
  • thorax compression via mechanical device (LUCAS 3)
  • head up cpr
  • use of an ITD module
  • arterial line placement
  • continuous epinephrin infusion via infusion pump
  • double sequence defibrillation

ERC ALS 2025

Procedure

Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces

Primary outcomes

  1. ROSC

    Time frame: one minute

    frequency of ROSC in the study cohort

Secondary outcomes

  1. Time to ROSC

    Time frame: Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)

    comparison between the groups if ROSC can be achieved faster in one group

  2. CO2

    Time frame: Periprocedural: from enrollement to ROSC orTOR

    Measurement of CO2 differences between study arms

  3. descriptive data

    Time frame: Periprocedural: during study intervention

    analyzing vital parameters measured

Sponsors and collaborators

Lead sponsor

Johannes Kepler University of Linz

Other

Collaborators

  • Kepler University Hospital
  • Red Cross Upper Austria

Registry information

Official study title

Adapted CPR (aCPR) a Bundle of Measures for Out of Hospital Cardiac Arrest (OHCA) Patients

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Aug 10, 2026
Registry last updated
Aug 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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