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OpenTrials
Completed

NCT Number: NCT04844255

Acute Salt Sensitivity of Blood Pressure

Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.

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Key information

Conditions

Blood Pressure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Livingstone Central Hospital

Livingstone, Southern Province, 10101, Zambia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study)

Exclusion criteria

  • diabetes patients, ill participants

Treatment and study plan

dietary salt

Dietary Supplement

2 grams of dietary salt

Primary outcomes

  1. Acute salt sensitivity

    Time frame: 160 minutes

    Mean arterial pressure change of 10 mmHg

Secondary outcomes

  1. Diastolic blood pressure change

    Time frame: 160 minutes

    Diastolic blood pressure change of equal to or more than 10 mmHg

  2. Systolic blood pressure change

    Time frame: 160 minutes

    Systolic blood pressure change of equal to or more than 20 mmHg

Sponsors and collaborators

Lead sponsor

Mulungushi University

Other

Collaborators

  • University of Zambia

Registry information

Official study title

HIV Integrated Personalized Care Approach to the Prevention, Diagnosis, and Control of Salt-sensitive Hypertension: The HIPO CAP DICTSH STUDY

Acronym: AcuteSS

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Apr 14, 2021
Registry last updated
Apr 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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