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Completed

NCT Number: NCT03184636

Acute-On-Chronic Liver Failure in Zagazig University Hospitals

Rationale:

To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals.

The question of the research:

How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals?

The aim of the work:

The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals

Objectives:

To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals.

Subjects and Methods:

I . Technical Design:

* Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals * Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''.

II . OPERATIONAL DESIGN:

* Type of the study: a prospective study. * Full medical history - taking. * Full clinical examination. * Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time "

III. Administrative Design:

* Approvals obtained for performing the study from the official or governmental department. * An ethical committee from the faculty of medicine and patients included in the study.

Results:

Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods

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Key information

Conditions

Acute-On-Chronic Liver Failure Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure Liver Failure, Acute

Sex eligibility

All sexes

Study type

Observational

Primary location

Salem Mohamed

Zagazig, Sharqia Province, 44519, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Exclusion criteria

  • no any exclusion criteria

Treatment and study plan

Primary outcomes

  1. improvement of the patients score according to SOFA score (AASLD and EASL guidelines)

    Time frame: 24 weeks from first recruiting

    follow up of participants until the patients recover

Secondary outcomes

  1. death of the patient

    Time frame: 24 weeks from first recruiting

    due to the severity of acute on chronic failure, the death of patients is expected

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

ACLF in Zagazig University Hospitals

Acronym: ACLF

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jun 12, 2017
Registry last updated
Aug 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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