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Completed

NCT Number: NCT03370783

Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.

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Key information

Conditions

Alcohol Drinking Behavior Drinking Behavior

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brown University

Providence, Rhode Island, 02912, United States

About this study

The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages 21-45 years
  • Able to speak and read English at least at 8th grade level
  • Moderate self-reported alcohol use in the past year
  • Body mass index in normal to overweight range
  • Right-handed

Exclusion criteria

  • History of heavy drinking
  • Currently seeking alcohol or drug treatment
  • Chronic disease requiring use of medication
  • Recent antibiotic or probiotic use
  • Chronic daily use of NSAIDs
  • Chronic GI disorder
  • Use of illicit drugs
  • Major psychiatric disorder or suicidality
  • Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
  • Safety contraindication for MRI scan
  • Inability to abstain from use of tobacco products prior to or during study
  • Inability to abstain from use of cannabis prior to or during study
  • Pregnant, nursing, or may become pregnant

Treatment and study plan

Ethanol

Drug

Moderate alcohol consumption

Primary outcomes

  1. Immune biomarkers

    Time frame: 1-3 hours after alcohol intake

Sponsors and collaborators

Lead sponsor

Brown University

Other

Collaborators

  • National Institute of General Medical Sciences (NIGMS)

Registry information

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Dec 12, 2017
Registry last updated
Jul 20, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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