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Completed

NCT Number: NCT03830268

Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants

Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.

Completed

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Key information

Conditions

Ketonemia Acid-Base Imbalance Acidosis Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Ketosis Metabolic Diseases Nutritional and Metabolic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rearsh Centre on Aging

Sherbrooke, Quebec, J1H4C4, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 10 health young (20-40 y old) and 10 health older (> 60 y old) participants
  • Men and women

Exclusion criteria

  • smoking
  • diabetes (fasting glucose >7.0 mmol/l and glycated hemoglobin >6.9%)
  • strenuous aerobic exercise more than three times a week
  • untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function
  • under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)

Treatment and study plan

No MCT intake with breakfast, no lunch

Dietary Supplement

Water given with a regular standardize breakfast and water given at noon without lunch.

Other names: CTL

No MCT intake with lunch, no breakfast

Dietary Supplement

Water given in the beginning of the metabolic study day without breakfast and water given at noon with a regular standardize lunch.

Other names: CTL inverted

10g of Betaquik

Dietary Supplement

BQ10 given with a regular standardize breakfast and BQ10 given at noon without lunch.

Other names: BQ10

10g of Betaquik with low-carbs breakfast

Dietary Supplement

BQ10 given with a low-carbs standardize breakfast and BQ10 given at noon without lunch.

Other names: BQ10LC

20g of Betaquik

Dietary Supplement

BQ20 given with a regular standardize breakfast and BQ20 given at noon without lunch.

Other names: BQ20

10g of Betaquik with lunch, no breakfast

Dietary Supplement

BQ10 given in the beginning of the metabolic study day without breakfast and BQ10 given at noon with a regular standardize lunch.

Other names: BQ10 inverted

Primary outcomes

  1. Concentration of plasma ketones (acetoacetate and B-hydroxybutyrate)

    Time frame: 8 hours

    To compare acute ketonemia following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

Secondary outcomes

  1. Concentration of plasma glucose

    Time frame: 8 hours

    To compare acute glucose following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

  2. Concentration of plasma insulin

    Time frame: 8 hours

    To compare acute insulin following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

  3. Concentration of plasma free fatty acids

    Time frame: 8 hours

    To compare acute free fatty acids following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol.

Sponsors and collaborators

Lead sponsor

Université de Sherbrooke

Other

Registry information

Official study title

Optimisation of Acute Medium Chain Triglycerides Intake Characteristics on Different Plasma Metabolites in Young and Older Participants

Acronym: Opti-MCT

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Feb 5, 2019
Registry last updated
Mar 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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