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Completed

NCT Number: NCT06544538

Acute Kidney Injury After Cardiac Arrest

The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.

For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

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Key information

Conditions

Acute Kidney Injury Cardiovascular Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Arrest Heart Diseases Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bakırköy Dr. Sadi Konuk Training and Research Hospital

Istanbul, 34140, Turkey (Türkiye)

About this study

This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis.

Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

Exclusion criteria

  • Deaths in the first 48 hours
  • Missing data
  • End stage CKD or first day hemadsorption
  • CPR time <3 min
  • Unwitnessed cardiac arrest
  • Terminal malignancy
  • 90 years old
  • Having a pace marker
  • Massive bleeding
  • ECMO application
  • First day diyabetes insipitus

Treatment and study plan

Primary outcomes

  1. Acute Kidney Injury (AKI)

    Time frame: Within 48 hours after intensive care unit admission

    Creatinine values in the first 48 hours of intensive care unit admission after cardiac arrest

Secondary outcomes

  1. AKI incidence

    Time frame: Within 48 hours after intensive care unit admission

    Determination of the incidence of AKI development after cardiac arrest

  2. Mortality

    Time frame: Clinical and laboratory data within 48 hours after intensive care unit admission will be used

    Impact of AKI development on mortality in the early post-cardiac arrest period

Sponsors and collaborators

Lead sponsor

Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Other Gov

Registry information

Official study title

Causes and Clinical Outcomes of Acute Kidney Injury After Cardiac Arrest: A Retrospective Cohort Study

Important dates

Study start
2013
Primary completion
2022
Study completion
2022
First posted
Aug 9, 2024
Registry last updated
Aug 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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