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OpenTrials
Active, Not Recruiting

NCT Number: NCT05656651

Acute Immunological Effects of Exercise in Cancer Patients

The aim of the study is to evaluate and compare immune response to a single exercise intervention in cancer patients and healthy age-maged individuals.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Cancer Neoplasms

Age range

15 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University Hospital Essen

Essen, North Rhine-Westphalia, 45147, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adolescents and young adults >14 years of age
  • undergoing acute cancer treatment (chemotherapy)
  • signed informed consent

Exclusion criteria

  • Inability to follow and implement test instructions
  • medical contraindication to HIIT on cycle ergometer
  • chemotherapeutic treatment 48 h prior
  • Hb <8g/dl; platelets < 20,000/ul.

Treatment and study plan

High intensity interval exercise training

Behavioral

Endurance training adapted to age, resting heart rate

Other names: HIIT, Exercise

Primary outcomes

  1. Number of Natural Killer Cells

    Time frame: Change from pre Intervention to immediately after intervention and 1 hour post intervention

    NK cells, subgroups and innate lymphoid cells

Secondary outcomes

  1. Subjective Quality of Life

    Time frame: Once after intervention

    Quality of Life (EORTC QLQ-C30, questionnaire score from 0 - 100, higher score = better quality of life)

  2. Fatigue

    Time frame: Once after intervention

    Fatigue (EORTC QLQ FA12 Fatigue questionnaire range 0 - 100, higher score = worse outcome)

  3. Nutritional status

    Time frame: Once after intervention

    Mini Nutritional Assessment (MNA range 0 - 14 points), lower score = worse

Sponsors and collaborators

Lead sponsor

Universität Duisburg-Essen

Other

Registry information

Official study title

ACTIVE- Acute Effects of a Single Physical Exercise Intervention on Immune Cells and Inflammation in Cancer Patients and a Healthy Comparison Group

Acronym: ACTIVE

Important dates

Study start
2022
Primary completion
2024
Study completion
2026
First posted
Dec 19, 2022
Registry last updated
May 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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