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OpenTrials
Completed

NCT Number: NCT06466213

Acute Effects of Three Different Types Single Leg Exercise in Copd

COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. One leg exercise result is not enough to highlight these parameters.

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Key information

Conditions

Exercise Behavior Motor Activity

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Elif Kocaaga

Ankara, Turkey (Türkiye)

About this study

Acute Effects of Three Different Types Single Leg Exercise in Copd

single bout high intensity interval training

single bout continuous exercise training single bout resistance training

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COPD patients that applied to physiotherapy
  • cooperate to test
  • no severe ortopedical and neurological disease no severe cardiovascular disease volunteer to study

Exclusion criteria

  • have an acute exacerbation
  • hypoxemia [PaO2] <55 mmHg
  • no cooperated to test no volunteer to study having ortophedical and neurological diesase that affecting of tests having severe cardiovascular disease

Treatment and study plan

single exercise bout about one-leg exercise

Other

cycle exercise includes single leg

Primary outcomes

  1. six minute walk test

    Time frame: beginning, day 1

    six minute walk test in meter

Secondary outcomes

  1. cardiopulmonary exercise test

    Time frame: beginning, day 2

    VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test

  2. single leg extremity test

    Time frame: beginning, day 3

    VO2 max will be recorded as ml/kg/min will be recorded from incremental cycle cpet test

  3. lung function

    Time frame: beginning, day 1

    FVC in % , FEV1 in %, FEV1/FVC ratio, PEF in % and FEF 25-75 in %

  4. muscle strength (isometric)

    Time frame: beginning day 1

    quadriceps isometric muscle strength will be recorded as kilogram

  5. muscle strength (10 repeated max)

    Time frame: beginning, day 1

    quadriceps 10 repeated max muscle strength will be recorded as kilogram

  6. continous exercise acute (single leg)

    Time frame: beginning day 4

    VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session

  7. high intensity interval training acute exercise (single leg)

    Time frame: beginning day 5

    VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session

  8. strength training acute exercise (single leg)

    Time frame: beginning day 4,5,6

    VO2 max will be recorded as ml/kg/min will be performed from incremental cycle exercise at single session

  9. muscle oxygenation

    Time frame: beginning day 4,5,6

    minumum muscle oxygenation level will be presented as percentage

  10. arterial stifness

    Time frame: beginning day 2,3, 4,5,6

    Aıx@75 in %

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Acronym: COPD

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jun 20, 2024
Registry last updated
Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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