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OpenTrials
Completed

NCT Number: NCT06555484

Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.

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Key information

Age range

22 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Two Liberty Place

Philadelphia, Pennsylvania, 19102, United States

About this study

Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.

  • Provision of signed and dated informed consent form
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Adult (aged 22+)

Exclusion criteria

  • Patients who self-report diagnosis of respiratory-related conditions will be excluded.
  • Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.

Treatment and study plan

Cross Over Assignment Supplemental Oxygen and Supplemental Air

Device

Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing "supplemental air" (in an order randomly assigned).

Primary outcomes

  1. 2 back Memory test performance

    Time frame: At baseline and 5 mins post-intervention exposure

    # correct on 2-back test

  2. Memory test performance

    Time frame: At baseline and 5 mins post-intervention exposure

    New Medical Icons Spatial Test

Sponsors and collaborators

Lead sponsor

Inogen Inc.

Industry

Registry information

Official study title

Acute Effects of Supplemental Oxygen on Memory in Healthy Older Adults: a Double-Blind Within-Subject Crossover Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 15, 2024
Registry last updated
Jan 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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