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NCT Number: NCT07089537

Acute Effects of Progressive Muscle Relaxation on Brain Waves

In modern environments, stress is present regardless of age or social role. Stress does not always have negative effects; in fact, it is a necessary response for survival, known as the stress response. This response includes increased heart rate, blood pressure, blood glucose levels, and decreased alpha brainwave activity. These physiological changes are primarily regulated by the sympathetic and parasympathetic branches of the autonomic nervous system, enabling us to cope with environmental threats. However, when the stress response system becomes overwhelmed or imbalanced-whether due to accumulated chronic stress or acute stress-it may result in adverse effects on both physical and mental health.

Relaxation techniques are non-pharmacological methods that promote parasympathetic nervous system activity. The goal is to reduce excessive arousal, alleviate anxiety, slow down thought processes, and relieve stress, thereby achieving relaxation in a natural way. These methods help lower blood pressure, improve circulation, relax muscles, and enhance concentration. Previous studies have demonstrated a correlation between relaxation and attention, suggesting that relaxation can improve attentional efficiency. Moreover, it is well-documented that executive function tends to decline under stress. Relaxation techniques are commonly incorporated into psychological therapies, yet they are more accessible, easier to practice, and can be conveniently performed at home.

Therefore, the aim of this study is to investigate whether PMR can produce immediate relaxation effects as measured by EEG (cortical excitability), heart rate variability, and muscle tone, and whether it can improve performance under psychological stress. The goal is to further explore the potential application of PMR in healthy populations facing acute stress conditions.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kaohsiung Medical University

Kaohsiung City, 807378, Taiwan

Location status: Recruiting

Location contact

Hsinyu Sun

CONTACT

[email protected]

886+989663315

Prof. Hsu

CONTACT

[email protected]

886+73121101 ext. 2673

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults
  • Age: 18 years and above
  • Body Mass Index (BMI) between 18 and 24
  • Able to remain in a semi-recumbent position for 2 hours

Exclusion criteria

  • Individuals with communication impairments or difficulty understanding instructions
  • Color vision deficiency
  • Open wounds or injuries on the scalp
  • Currently taking medications that affect cardiovascular or autonomic nervous system regulation
  • Muscle strain or pain

Treatment and study plan

progressive muscle relaxaiton

Other

Participants will undergo approximately 30 minutes of Progressive Muscle Relaxation (PMR). Prior to the session, a brief introduction to the basic concepts of PMR will be provided. Participants will be instructed to close their eyes and focus on the sensations in their muscles. Following verbal instructions, they will sequentially contract and relax 14 major muscle groups from top to bottom. For each muscle group, participants will be asked to contract the muscles as strongly as possible for 7 seconds, followed by a 45-second relaxation period. This process will be repeated twice for each muscle group.

Rest

Other

Rest in a semi-recumbent position with eyes closed for 30 minutes, without any additional intervention.

Primary outcomes

  1. Electroencephalography

    Time frame: 20 min in total

    Analysis of changes in EEG band power excitability across the frontal, central, and occipital brain regions.

Secondary outcomes

  1. Muscle tension

    Time frame: 15 mins

    Changes in muscle tension

  2. heart rate variability

    Time frame: 20 mins in total

    changes in frequency domain heart rate variability

  3. Self-Assessment Manikin

    Time frame: 1min

    Whether the subjective emotion is calm or excited

Study contacts

Contact information is provided by the study sponsor or research team.

Hsinyu Sun

CONTACT

[email protected]

886+989663315

Miaoju Hsu

CONTACT

[email protected]

886+73121101 ext. 2673

Sponsors and collaborators

Lead sponsor

Kaohsiung Medical University

Other

Registry information

Official study title

Acute Effects of Progressive Muscle Relaxation on Brain Waves, Heart Rate Variability, Muscle Tone, and Mental Stress

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 28, 2025
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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