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NCT Number: NCT06663267

Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:

1. How do meteorological factors and air pollution affect cardiovascular system? 2. What is the interaction between meteorological factors and air pollution on cardiovascular system?

Participants will:

1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound. 2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

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Key information

Conditions

Cardiovascular System Health

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

MingWei Wang

Hanzhou, Zhejiang, 310000, China

Location status: Recruiting

Location contact

MingWei W Wang, PhD

CONTACT

[email protected]

86-18758871517 ext. NOT

About this study

The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

·Relevant records in the physical examination database shall be ≥3 times

·≥18 years old

Exclusion criteria

  • Relevant records in the physical examination database shall be ≥３times
  • Serious heart and lung diseases
  • Malignant tumors
  • Serious mental illness in the past

Treatment and study plan

NOT

Other

This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.

Primary outcomes

  1. Troponin

    Time frame: The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L.

  2. Blood pressure

    Time frame: The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg.

Secondary outcomes

  1. Left ventricular ejection fraction（LVEF）

    Time frame: The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Left ventricular ejection fraction（LVEF）data were obtained by Cardiac color ultrasound data recorded in the diagnosis and treatment system, with unit of %

  2. White cell count

    Time frame: The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    White cell count data were obtained by blood routine blood data recorded in the diagnosis and treatment system, with unit of 10^9/L

  3. Controlled Attenuation Parameter（CAP）

    Time frame: The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Controlled Attenuation Parameter（CAP）data were obtained by Diagnosis of hepatic fibrosis data recorded in the diagnosis and treatment system, with unit of dB/m.

  4. ST segment of electrocardiogram

    Time frame: The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    ST segment were obtained by Electrocardiogram (ECG) recorded in the diagnosis and treatment system with unit of mV.

  5. Degree of coronary artery stenosis

    Time frame: The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Degree of coronary artery stenosis data were obtained by Coronary CTA data recorded in the diagnosis and treatment system, with unit of µg/L

  6. Weight

    Time frame: The weight data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Weight data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of kg

  7. Height

    Time frame: The height data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Height data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of cm

  8. Urinary glucose

    Time frame: The urinary glucose data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

    Urinary glucose data were obtained by Urine routine data recorded in the diagnosis and treatment system, with unit of mmol/L.

Study contacts

Contact information is provided by the study sponsor or research team.

Mingwei W Wang, PhD

CONTACT

[email protected]

18758871517 ext. not

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Hangzhou Normal University

Other

Registry information

Important dates

Study start
2024
Primary completion
2027
Study completion
2028
First posted
Oct 29, 2024
Registry last updated
Oct 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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