Acute Effects of Exercise on the Cortical Silent Period in Prostate Cancer Patients

Inclusion criteria

• Histologically confirmed PCa;
• > 6 months post curative therapy for PCa (radical prostatectomy or radiation therapy) with or without adjuvant androgen deprivation therapy;
• Willing and able to provide informed consent;
• If metastatic disease is present, they are asymptomatic; v) n
• No contraindications to exercise

Exclusion criteria

• Severe coronary artery disease (Canadian Cardiovascular Society class III or greater);
• Significant congestive heart failure (New York Heart Association class III or greater);
• Uncontrolled pain;
• Neurological or musculoskeletal co-morbidity inhibiting exercise;
• Diagnosed psychotic, addictive, or major cognitive disorders or are currently or have a history of using psychotropic medication (anti-depressants, anti-anxiety, anti-psychotics, benzodiazepines, etc);
• Contraindications to magnetic exposure (surgical clips in the brain; cardiac pace maker or valves; cochlear implants; metal rods, plates, screws in head; shrapnel/metal fragments in head/eyes; dentures);
• Prior history of seizures or diagnosis of epilepsy;
• Left-hand dominant; and
• No more than two of the following Coronary Risk Factors as defined by the American College of Sports Medicine[41, 42]:

• Family history of coronary disease, cigarette smoking, hypertension (Systolic Blood Pressure (SBP) > 140 mmHg; Diastolic Blood Pressure (DBP) > 90 mmHg), known dyslipidemia, known impaired fasting, glucose (>110 mg/dL), obesity (BMI > 30 kg/m2 or waist circumference > 102cm), or physically inactive (<150 min of moderate intensity physical activity per week)