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Completed

NCT Number: NCT06368271

Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

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Key information

Conditions

Healthy Nutrition Diet, Healthy

Age range

20 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutrition, Exercise and Sports, Copenhagen, Denmark

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About this study

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy males BMI:20-27 recreationally physical active non-smoker no medicine

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Exclusion criteria

  • high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

Treatment and study plan

Lipidomics

Dietary Supplement

Health beneficial effects of medium-chain fatty acids

Primary outcomes

  1. Meal test including medium-chain fatty acids

    Time frame: 0-4 hours

    In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile

Secondary outcomes

  1. Resting metabolic rate

    Time frame: 0-4 hours

    The secondary outcome of this study is to investigate the effect of an acute intake of MCT or LCT oil (35g of MCT or LCT) on resting metabolic rate in healthy lean men

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Official study title

Acute Effects of Dietary Medium-chain Fatty Acids on Llipid Profile

Acronym: Lipidomix

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Apr 16, 2024
Registry last updated
Apr 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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