University of Illinois at Urbana-Champaign
Urbana, Illinois, 61801, United States
NCT Number: NCT05078203
The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims:
Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity.
Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity.
Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.
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Notify Me18 year–35 year
All sexes
Interventional
Not applicable
Urbana, Illinois, 61801, United States
18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order. A cognitive testing battery accompanied by an electroencephalogram (EEG) will be administered following each session. Blood samples will be collected prior to, during, and following each throughout each testing condition.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
36 minutes of Exercise
Time frame: 3 hours
Changes in peripheral myokine concentration
Time frame: 3 hours
Behavioral performance measured as accuracy (%) during Flanker task
Time frame: 3 hours
Behavioral performance measured as response time (ms) during Flanker task
Time frame: 3 hours
Changes in P3 event related potential amplitude (microvolts) using a computerized flanker task
Time frame: 3 hours
Changes in P3 event related potential latency (ms) using a computerized flanker task
Time frame: 3 hours
Accuracy during a spatial reconstruction task
Time frame: 3 hours
Changes in peripheral BDNF concentration
University of Illinois at Urbana-Champaign
Other
Acute Exercise and Cognitive Function: Examining the Role of Weight Status and Exercise-Induced Myokines
Acronym: ACE
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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