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OpenTrials
Completed

NCT Number: NCT05078203

Acute Cognition and Exercise

The central hypothesis is that, while both groups will benefit from the exercise session, participants with obesity will exhibit greater gains in cognitive control, relative to healthy weight adults. Additionally, it is anticipated that the benefits of a single bout of exercise for cognitive control will be mediated by changes in exercise-induced myokines. These hypotheses will be tested by accomplishing three aims:

Aim 1: Elucidate the changes in cognitive control following an acute bout of exercise, relative to a sedentary condition, in persons with and without obesity.

Aim 2: To examine the effect of a single bout of exercise, relative to a sedentary condition, on myokines known to have neuroprotective effects i.e., BDNF and CTSB in both healthy weight and individuals with obesity.

Aim 3: To link changes in exercise-induced myokines (i.e., BDNF and CTSB) to changes in cognitive function, following a single bout of exercise.

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

About this study

18 adults with healthy weight (BMI 18.5-25.0kg/m2) and 18 adults with obesity (BMI 30.0kg/m2) will be asked to complete a counter-balanced crossover trial. After initial baseline testing, participants will be asked to complete either an acute exercise bout or sedentary control session in a counter-balanced order. A cognitive testing battery accompanied by an electroencephalogram (EEG) will be administered following each session. Blood samples will be collected prior to, during, and following each throughout each testing condition.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between ages 18 and 35
  • No prior diagnosis of neurological disorders (e.g., autism spectrum disorder)
  • No prior diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
  • No physical disability that would preclude the participant from completing a VO2max test
  • Corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
  • Not pregnant
  • BMI between 18.5 and 25.0 kg/m2, or BMI greater than 30.0 kg/m2
  • Readiness for exercise (determined through PAR-Q)

Exclusion criteria

  • <18 years and >35 years
  • Diagnosis of neurological disorders (e.g., autism spectrum disorder)
  • Diagnosis of metabolic disease (e.g., diabetes, cardiovascular disease)
  • Physical disability that would preclude the participant from completing a VO2max test
  • Lack of corrected vision (based on the minimal 20/20 standard needed to complete cognitive tasks)
  • Pregnancy
  • BMI less than 18.5 kg/m2 or BMI greater than 25.0 but less than 30.0 kg/m2

Treatment and study plan

Exercise

Behavioral

36 minutes of Exercise

Primary outcomes

  1. Circulating Cathepsin B (CTSB) Myokine

    Time frame: 3 hours

    Changes in peripheral myokine concentration

  2. Attentional Inhibition Accuracy

    Time frame: 3 hours

    Behavioral performance measured as accuracy (%) during Flanker task

  3. Attentional Inhibition Reaction Time

    Time frame: 3 hours

    Behavioral performance measured as response time (ms) during Flanker task

  4. Attentional Resource Allocation

    Time frame: 3 hours

    Changes in P3 event related potential amplitude (microvolts) using a computerized flanker task

  5. Attentional Processing Speed

    Time frame: 3 hours

    Changes in P3 event related potential latency (ms) using a computerized flanker task

  6. Relational Memory

    Time frame: 3 hours

    Accuracy during a spatial reconstruction task

Secondary outcomes

  1. Brain derived neurotrophic factor (BDNF)

    Time frame: 3 hours

    Changes in peripheral BDNF concentration

Sponsors and collaborators

Lead sponsor

University of Illinois at Urbana-Champaign

Other

Registry information

Official study title

Acute Exercise and Cognitive Function: Examining the Role of Weight Status and Exercise-Induced Myokines

Acronym: ACE

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Oct 14, 2021
Registry last updated
Feb 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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