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NCT Number: NCT06248151

Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-COVID-19 Syndrome

The objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by Covid-19 with and without persistent symptoms.

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Key information

Conditions

Post-Acute COVID-19 Syndrome COVID-19 Chronic Disease Coronaviridae Infections Coronavirus Infections Disease Attributes Fatigue Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Nove de Julho

São Paulo, 01504-001, Brazil

Location status: Recruiting

Location contact

Raphael Dias

CONTACT

About this study

The study will be a crossover carried out in two groups (with and without persistent symptoms of Covid-19). Participants in both groups will undergo a control session and an exercise session and cardiorespiratory and perceptual responses will be obtained before, during and after the sessions. In the exercise session, participants will perform aerobic exercises, strength exercises and muscle stretching, while in the control session participants will remain seated. Blood pressure, heart rate, cardiac autonomic modulation, peripheral oxygen saturation, vascular function and perception of affect will be obtained.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Post-Covid Syndrome group:

  • have had a positive RT-PCR test for Covid-19;
  • present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
  • have the cognitive and physical capacity to perform the exercises; It is
  • low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Healthy group:

  • not present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
  • have the cognitive and physical capacity to perform the exercises; It is
  • low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Treatment and study plan

Exercise session

Behavioral

Session will included aerobic, resistance and flexibility exercises and will last approximately 45 minutes. The session will begin with aerobic exercises (5 min jumping jacks and 5 min stationary walking). Then, nine strength exercises will be performed for the main muscle groups (3 times of 12 to 15 repetitions, with a 1-minute rest interval) and finally stretching for the main muscle groups

Other names: Rehabilitation, Cardiorespiratory exercises, Resistance exercises, Flexibility

Control session

Behavioral

Remain seated for 60 min

Primary outcomes

  1. Change in Blood pressure

    Time frame: Before and 30 and 50 minutes after the end of the exercise and control interventions

    Assessment of the systolic and diastolic blood pressure using an automatic device

  2. Change in Heart rate variability

    Time frame: Before and 30 and 50 minutes after the end of the exercise and control interventions

    Assessment of the heart rate variability indicators using a heart rate monitor

  3. Change in flow mediated dilation

    Time frame: Before and 30 minutes after the end of the exercise and control interventions

    Assessment of the flow mediated dilation using a doppler ultrasound

  4. Change in peak exhalation flow

    Time frame: Before and 5 minutes after the end of the exercise and control interventions

    Assessment of the peak exhalation flow using a peak flow device

  5. Change in oxygen saturation

    Time frame: Before, during and 5 minutes after the end of the exercise and control interventions

    Assessment of the peripheral oxygen saturation using a pulse oximeter

Secondary outcomes

  1. Change in heart rate

    Time frame: Before and continuously during exercise and control interventions

    Assessment of heart rate using a heart rate monitor

  2. Change in affective response

    Time frame: Before and every 5 minutes during exercise and control interventions

    Assessment of affective response using a felling scale

Study contacts

Contact information is provided by the study sponsor or research team.

Marilia Correia, PhD

CONTACT

[email protected]

+5511999711669

Raphael Dias, PhD

CONTACT

[email protected]

+5519999406878

Sponsors and collaborators

Lead sponsor

University of Nove de Julho

Other

Registry information

Acronym: ExPostCovid-19

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Feb 8, 2024
Registry last updated
Dec 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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