CHU de Bordeaux
Bordeaux, 33 076, France
NCT Number: NCT04426188
Soccer, the most popular sport in the world, exposes players to repeated head impacts and concussions, due to contact with another player or with the ground. Moreover, routine game-play in soccer involves intentional and repeated head impacts through ball "heading", with frequent high velocities, which might cause a transient brain dysfunction. In this pre-post prospective interventional study, 22 soccer players will perform 10 headers from machine-projected soccer balls at standardized speeds, modelling routine soccer practice. They will perform heading series in 2 different oral conditions, on different days at least 1 week apart: 1) Without mouthguard and tight jaws ; 2) With mouthguard and tight jaws. The strength of the neck muscles will be measured before the heading series. The kinematic of the movement will be recorded during each impact during the 2 heading series, as well as the activity of the jaw muscles which will be recorded by electromyogram. Before and after each heading series, electrophysiological data, multimodal magnetic resonance imaging (MRI), and cognitive computerized assessment will be acquired
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Notify Me18 year–25 year
Male
Interventional
Not applicable
Bordeaux, 33 076, France
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Male 18 to 25 years, enrolled in French Social Security, recruited from the soccer teams of the University of Bordeaux
Exclusion criteria
10 headers from machine-projected soccer balls at standardized speeds
Brain MRI before and after a series
Cognitive evaluation carried out with two computerized tools
Electrophysiological recording of Motor Evoked Potentials consisting of the application of transcranial magnetic stimulations (TMS) and the collection of muscle activity by electromyogram (EMG)
Measure of the strength of the neck muscles using a dynamometer
Time frame: Week 4
Mean linear and rotational acceleration of the head
Time frame: Week 6
Mean linear and rotational acceleration of the head
Time frame: Week 4
Corticomotor inhibition measured in milliseconds using transcranial magnetic stimulation and electromyographic recordings.
Time frame: Week 6
Corticomotor inhibition measured in milliseconds using transcranial magnetic stimulation and electromyographic recordings.
Time frame: Week 4
Normalized score (Z-score) on the subtests of the computerized cognitive battery
Time frame: Week 6
Normalized score (Z-score) on the subtests of the computerized cognitive battery
Time frame: Week 4
Average time on the subtests of the computerized cognitive battery
Time frame: Week 6
Average time on the subtests of the computerized cognitive battery
Time frame: Week 4
Mean strength ratio between flexor and extensor muscles of the neck measured in Newton using a dynamometer
Time frame: Week 6
Mean strength ratio between flexor and extensor muscles of the neck measured in Newton using a dynamometer
Time frame: Week 4
Functional connectivity at rest in MRI
Time frame: Week 6
Functional connectivity at rest in MRI
University Hospital, Bordeaux
Other
" Brain Changes After Repetitive Head Impacts in Soccer and the Effects of a Protective Device: Biomechanical, Cognitive, Electrophysiological and Multimodal Neuroimaging Study "
Acronym: Soccer-BRAIN
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