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OpenTrials
Completed

NCT Number: NCT03095677

Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects

The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.

The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.

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Key information

Conditions

Apnea Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CHR d'Orléans

Orléans, 45067, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
  • Subjects will have to sign the inform consent before the beginning of the study

Exclusion criteria

  • Contraindications to regular physical exercise practice
  • To practice an endurance sport more than 1h/week
  • Regular practice of apnea
  • Chronic use of cannabis and/or alcohol
  • Cardiac or metabolic pathology
  • Asthma and/or bronchodilatator treatment
  • ECG abnormality at rest
  • Regular consumption of tobacco

Treatment and study plan

Program of training with exercises including apnea

Other

16 training session on cycle ergometry with exercises including apneas.

Program of training with exercises without apnea

Other

16 training session on cycle ergometry with exercises without apnea

Primary outcomes

  1. Spectometry to measure hemoglobin rate

    Time frame: 3 weeks

    Measurement of oxygenation

  2. Wingate test to measure maximum consumption of dioxygen

    Time frame: 3 weeks

    Measurement of aerobic performance

  3. Measurement of hormonal markers

    Time frame: 3 weeks

    Measurement of Dehydroepiandrostenedione (DHEA)

  4. Jaeger debimeter system to measure of peak oxygen

    Time frame: 3 weeks

    Measurement of oxygen consumptiom

  5. Measurement of arterial saturation in dioxygen

    Time frame: 3 weeks

    Measurement by ear blood micro-sample

  6. Spectometry to measure hemoglobin

    Time frame: 12 weeks

    Measurement of oxygenation

  7. Measurement of hormonal markers

    Time frame: 12 weeks

    Measurement of Dehydroepiandrostenedione (DHEA)

  8. Jaeger debimeter system to measure of peak oxygen

    Time frame: 12 weeks

    Measurement of oxygen consumption,

  9. Measurement of arterial saturation in dioxygen

    Time frame: 12 weeks

    Measurement by ear blood micro-sample

Secondary outcomes

  1. Cardiac frequency

    Time frame: 3 weeks

    measurement with a 12 lead - Electrocardiogamm

  2. Cardiac frequency

    Time frame: 12 weeks

    measurement with a 12 lead - Electrocardiogramm

  3. Borg scale to measure penibility of the effort

    Time frame: week 3

  4. Borg scale to measure penibility of the effort

    Time frame: week 12

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional d'Orléans

Other

Collaborators

  • Laboratoire de Complexité, Innovation et Activités Motrices et Sportives

Registry information

Acronym: APNEX

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Mar 30, 2017
Registry last updated
May 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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