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OpenTrials
Completed

NCT Number: NCT00201474

Acute, Affective, Organic Disorders.

The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.

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Key information

Conditions

Depressive Disorders Brain Diseases Central Nervous System Diseases Depressive Disorder Epilepsy Mental Disorders Mood Disorders Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Østmarka Psychiatric Department, St. Olavs Hospital

Trondheim, 7441, Norway

About this study

A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.

In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acutely admitted psychiatric patients who have at different times the last 2 weeks filled criteria for at least two new DSM-4 Axis 1 psychiatric diagnoses. One of them has to be a depressive episode (MADRS>20)

Exclusion criteria

  • Patients not speaking Norwegian or English.
  • Patients not willing to participate.
  • Patients with dementia or mental retardation to an extensive degree.

Treatment and study plan

Primary outcomes

  1. epilepsy or an other organic brain disorder

    Time frame: 1 week

    EEG and QEEG are taken three times in the first week

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

  • Dr. Dedichens Institute for Psychiatric Research, Oslo, Norway.
  • GlaxoSmithKline
  • St. Olavs Hospital

Registry information

Official study title

Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.

Important dates

Study start
1998
Primary completion
2004
Study completion
2010
First posted
Sep 20, 2005
Registry last updated
Aug 4, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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