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NCT Number: NCT06939517

Acupressure Wristbands for GLP-1RA Related Nausea

Nausea is a common side effect of GLP-1RA medications used for treatment of Type 2 diabetes mellitus and obesity. Current recommendations for nausea relief include the use of dietary changes and prescription anti-emetics. Acupressure wristbands Sea-Band are FDA cleared for nausea relief in other indications such as motion sickness, morning sickness in pregnancy, post-operative nausea, chemotherapy associated nausea. We hypothesized that acupressure wristbands could alleviate nausea in persons taking GLP-1RA.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Nausea Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Evexia Medical

Jupiter, Florida, 33458, United States

About this study

Nausea is the most commonly reported side effect of the class of drugs collectively known as glucagon like peptide-1 receptor agonists (GLP-1RA). GLP-1RAs are FDA approved to treat Type 2 diabetes mellitus (T2DM) and Obesity. Sea-Band is an FDA-cleared set of drug-free elastic wristbands used for nausea relief in several indications including motion sickness, morning sickness in pregnancy, post-operative nausea, chemotherapy associated nausea in persons ages 3 years old and up. The elastic wristbands have a plastic skin facing knob that apples pressure to an acupressure point called pericardium 6 (P6) located below the crease of the wrist. We hypothesize that Sea-Band can alleviate nausea in persons taking GLP-1RA. Participants on GLP-1RA medication with nausea were offered a set of Acupressure wristbands, and followed for four weeks. Weekly touch points assessed the response to nausea relief of the bands. Eligibility for the study included Adults taking GLP-1RA experiencing nausea.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults taking GLp-1RA with nausea

Exclusion criteria

  • Adults on GLP-1RA without nausea
  • Uncontrolled GERD
  • Hx of Gastroparesis
  • Other nausea related conditions such as vertigo
  • History of chronic use of antiemetic medication for other reasons

Treatment and study plan

SeaBand

Device

Drug-free, reusable Acupressure elastic wristbands applied to bilateral wrists for nausea relief

Primary outcomes

  1. Nausea relief

    Time frame: Nausea relief with use of wristbands for every recorded episode, reviewed weekly, for a total of four weeks

    Participants will be asked to apply the wristbands at the onset of nausea, and record each nausea episode using a tracker. Weekly touch points with the study team will review their number of nausea episodes, and if nausea relief was obtained.

Secondary outcomes

  1. Time to onset of relief

    Time frame: Time to nausea relief with use of wristbands for every recorded episode, reviewed weekly, for a total of four weeks

    Participants will be asked to apply the wristbands at the onset of nausea, and record each nausea episode, confirm use of wristbands, and if time to relief was under five minutes using a tracker. Weekly touch points with the study team will review their nausea episodes. If relief was obtained, time to relief will be assessed as under or over five minutes.

Sponsors and collaborators

Lead sponsor

Florencia Ziemke

Other

Registry information

Official study title

Antiemetic Effect of Acupressure Wristbands for GLP-1RA Related Nausea

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Apr 23, 2025
Registry last updated
Apr 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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