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NCT Number: NCT06521632

Acupoint Stimulation Improves Cognition Under Hypoxia

Cognitive impairment is common in people who suffer from hypoxia. Acupuncture and related techniques can be used to improve hypoxia and treat cognitive impairment. In this trial the effect of transcutaneous electrical acupoint stimulation on cognitive impairment in people under hypoxia will be investigated.

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Key information

Conditions

Cognition Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male, age from 18 to 50 years

Exclusion criteria

  • cardiopulmonary dysfunction;
  • History of severe respiratory, circulatory, digestive, blood, ear-nose-throat system diseases;
  • A history of fever or respiratory infection within the last two weeks;
  • Drinking alcohol or poor sleep within the last 24 hours

Treatment and study plan

transcutaneous electrical acupoint stimulation

Other

Electrodes are placed at acupoints and connected to the stimulator. Electrical stimulation is given for 2 hours.

Primary outcomes

  1. cognitive function measured by eye-tracking at 1 hour after hypoxia

    Time frame: 1 hour after hypoxia

  2. cognitive function measured by eye-tracking at 2 hours after hypoxia

    Time frame: 2 hours after hypoxia

Secondary outcomes

  1. mean arterial blood pressure

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  2. heart rate

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  3. saturation of pulse oximetry

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  4. Cerebral oxygen saturation

    Time frame: starting from 10 minutes before hypoxia to 2 hours after hypoxia, every 5 minutes for 2 hours and 10 minutes

  5. total sleep time on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

  6. sleep efficiency(%) on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

    sleep efficiency=total sleep time/total recording time

  7. number of awake on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

  8. time of awake on the first day after hypoxia

    Time frame: the first day after hypoxia, in a total of 24 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Zhihong Lu

CONTACT

[email protected]

+8613891975018

Sponsors and collaborators

Lead sponsor

Zhihong LU

Other

Registry information

Official study title

Effect of Transcutaneous Electrical Acupoint Stimulation on Cognitive Function Under Exposure to Hypoxia

Acronym: TREACLE

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 26, 2024
Registry last updated
Jul 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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