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OpenTrials
Completed

NCT Number: NCT04897373

Active Older Adult Program on Health and Well-being

The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging

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Key information

Conditions

Older Adult

Age range

55 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women age 55 years or older.
  • Membership at the DAHLC.
  • New to AOA (Active Older Adult) Program and commitment to full participation in the twelve-week program.
  • Must be able to get down and off the floor with little assistance.

Exclusion criteria

  • Inability to provide informed consent.
  • Previous participation in the AOA Program at the DAHLC.

Treatment and study plan

Primary outcomes

  1. Change in repeated chair rise time

    Time frame: Baseline to end of study, approximately 14 weeks

    Chair stand test where participants will perform a chair rise movement for five repetitions. The series of 5 repetitions will be timed and measured in seconds.

  2. Change in plasma protein levels reflective of biological age

    Time frame: Baseline, week 12

    Blood samples will be obtained at baseline and at 12 weeks. The concentration of target proteins (pg/mL) in the plasma will be measured and compared between baseline and week 12.

  3. Change in expression of senescence-related genes in blood cells

    Time frame: Baseline, week 12

    Blood samples will be obtained at baseline and at 12 weeks. The expression of senescence-related genes (arbitrary units) will be measured in immune cells isolated from whole blood and compared between baseline and week 12.

Secondary outcomes

  1. Change in Self-reported Physical Function

    Time frame: Baseline, week 12

    Measured using the Physical Component Scale (PCS) from the 12-Item short form general health survey (SF-12).

  2. Change in Performance-based Physical Function

    Time frame: Baseline, week 12

    Measured using the timed up-and-go test (seconds to complete).

  3. Change in Mental Function

    Time frame: Baseline, week 12

    Measured using the Mental Component Scale (MCS) from the 12-Item short form general health survey (SF-12)

  4. Change in self-assessment of well-being

    Time frame: Baseline, week 12

    Measured using a linear analogue self-assessment scale of well-being from 0 ("as bad as it can be") to 10 ("as good as it can be") of mental, physical, emotional, and spiritual well-being, level of social activity, and overall quality of life during the past week

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

The Effects of an Active Older Adult Program at the Dan Abraham Healthy Living Center on Health and Well-being

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
May 21, 2021
Registry last updated
May 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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