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OpenTrials
Completed

NCT Number: NCT04455425

Acquired Syphlis by Non Sexual Contact

Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.

However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.

The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.

The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.

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Key information

Conditions

Syphilis Acquired Syphilis Infection

Age range

0 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital de Niños Ricardo Gutierrez

Buenos Aires, Buenos Aires F.D., 1425, Argentina

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children with treponemic and non-treponemic positive tests with primary or secondary-syphilis suspicious lesions

Exclusion criteria

  • Children with diagnose criteria positive for Congenital syphilis

Treatment and study plan

Primary outcomes

  1. Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis

    Time frame: Past 20 years

    Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed

  2. Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts

    Time frame: Past 20 years

    Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

  3. Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts

    Time frame: Past 20 years

    Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening

Sponsors and collaborators

Lead sponsor

Hospital de Niños R. Gutierrez de Buenos Aires

Other

Registry information

Official study title

Descriptive Cohort of Acquired Syphlis by Non Sexual Contact

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jul 2, 2020
Registry last updated
Mar 1, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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