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NCT Number: NCT07209488

Acquired Dyslexia Modeling and Treatment

This study is a low-risk, early phase 1, multicenter trial to test the use of a computational (neural network) cognitive model of reading to simulate acquired dyslexia and its treatment. The aim is to determine whether there is an advantage to receiving the treatment the model predicts to be advantageous compared to the alternative treatment. All participants will receive two full rounds of treatment. A round of treatment will consist of either phonomotor treatment (PMT) or semantic feature analysis (SFA) for 60 hours, distributed over 5 days a week for 2 hours a day.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fluent in English as a first language pre-stroke by self report.
  • Normal or corrected-to-normal vision.
  • Normal or aided hearing.
  • Left hemisphere ischemic or hemorrhagic stroke (as verified by a structural brain scan).
  • Impaired reading as confirmed by significant impairment in the Basic Skills cluster of the Woodcock Reading Mastery Test - III.

Exclusion criteria

  • Diagnosed pre-stroke neurological disease affecting the brain other than left hemisphere stroke.
  • Severe apraxia of speech (determined by consensus judgment among speech-language pathologists).
  • History of learning disabilities such as developmental dyslexia or current self-reported major psychiatric disorders.
  • Inability to undergo, or provide a copy of, a post-stroke brain imaging scan.

Treatment and study plan

Phono-Motor Therapy

Behavioral

Orthographic stimuli (letters) are introduced from the beginning as each phoneme is being trained. This maintains the focus on phonology, while emphasizing its relevance to reading. PMT consists of an initial phase focused on training of individual phonemes and phoneme sequences in spoken language, followed by written language tasks. English phonemes are first trained in isolation, followed by phoneme sequences in words and pseudowords. They are trained multi-modally through emphasis on auditory, motor, tactile-kinesthetic, visual, and orthographic representations for each consonant and vowel. When sequences are introduced, focus on phonology is maintained by training on pseudowords first before real words are introduced. Participants work on identifying, repeating, parsing, blending, and manipulating phonemes that make up the pseudoword and word stimuli. To maintain focus on phonology, pictures and definitions of the stimuli are never shown or discussed.

Other names: PMT

Semantic feature analysis

Behavioral

SFA activates semantic features of the target word to help retrieve the spoken form of the word. To target reading, a modified SFA is used with written words rather than pictures as the primary materials. Pictures are instead included for each word as a semantic feature. Stimuli will consist of 80 highly imageable nouns with a range of word frequencies. During treatment the therapist will present a written noun and ask the participant a series of questions about the features of that noun. For example, if the presented noun is "juice", the therapist would have the participant select the corresponding picture from an array of pictures. The therapist then would ask, "what do you do with it?" (eliciting a feature from the "function" category) and "where do you store it in your home?" (eliciting a feature from the "context" category). This is done for a total of 6 categories of semantic features. The process is repeated until the participant reads the noun correctly three times in a row.

Other names: SFA

Primary outcomes

  1. Woodcock Reading Mastery Test - III

    Time frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.

    The WRMT-III is a standardized measure of reading skills.

  2. Test words and pseudowords

    Time frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.

    Change in accuracy of reading 120 test words and 80 pseudowords

Secondary outcomes

  1. Western Aphasia Battery - Revised

    Time frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.

    The WAB - R is a standard measure of aphasia severity. It determines both the degree of aphasia and whether treatment has any impact on aspects of aphasia other than acquired dyslexia.

  2. Comprehensive Aphasia Test - Disability Quotient

    Time frame: Baseline, following the first 60 hours of therapy, and following the final 60 hours of therapy.

    The CAT - DQ is a self-report measure of subjectively perceived degree of disability.

Study contacts

Contact information is provided by the study sponsor or research team.

Olga Boukrina, PhD

CONTACT

[email protected]

973-324-3587

William W Graves, PhD

CONTACT

[email protected]

973-353-3947

Sponsors and collaborators

Lead sponsor

Rutgers, The State University of New Jersey

Other

Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

Registry information

Official study title

Evidence-based Modeling for Acquired Dyslexia Treatments

Acronym: AMT

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 7, 2025
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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