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Completed

NCT Number: NCT00541801

Acoustic Cardiographic Assessment of Heart Function in Comparison to Doppler-echocardiography

In this study, the investigators sought to determine whether an acoustic cardiographic assessment of heart function is equivalent to Doppler-echocardiography in patients who are treated with cardio-toxic cytostatic agents.

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Key information

Conditions

Heart Failure, Congestive Antineoplastic Agents Cardiovascular Diseases Heart Diseases Heart Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kantonsspital Luzern, Department of Cardiology

Lucerne, Canton of Lucerne, 6000, Switzerland

About this study

Patients receiving cardio-toxic cytostatic agents are examined by Doppler-echocardiography and acoustic cardiography before, during, and after the cytostatic treatment. Doppler-echocardiography measures ejection fraction, TDI, speckle tracking, and further parameters. Acoustic cardiography (Audicor, Inovise Medical Inc., Portland, USA) simultaneously integrates heart sounds and single-channel electrocardiography input to generate multiple parameters that correlate to established hemodynamic measures. Heart function as assessed by Doppler-echocardiography is then compared to the heart function as assessed by Audicor ECG.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with malignant disease with scheduled anthracycline and trastuzumab therapy

Treatment and study plan

Doppler-echocardiography and acoustic cardiography

Device

Patients receive a Doppler-echocardiography and an acoustic cardiography

Primary outcomes

  1. Changes of echocardiographic parameters and changes of electromechanical activation time (EMAT)and development of third heart sound as indicators of congestive heart failure

    Time frame: Repeated measurements over a year

Secondary outcomes

  1. Development of clinically overt congestive heart failure

    Time frame: One year

Sponsors and collaborators

Lead sponsor

Luzerner Kantonsspital

Other

Collaborators

  • Inovise Medical

Registry information

Official study title

Acoustic Cardiographic Assessment of Heart Function in Comparison to Doppler-echocardiography in Patients With Cytostatic Therapies

Important dates

Study start
2007
Primary completion
2011
Study completion
2011
First posted
Oct 10, 2007
Registry last updated
Jun 27, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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