Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura

Inclusion criteria

• Diagnosis of migraine with aura code
• At least 1 aura with aura per month in the 3 months prior to inclusion
• No prophylactic antimigraine treatment for at least 1 month prior to inclusion
• For women of childbearing age, use of a reliable contraceptive method at least 3 months before and 1 month after the study
• Signature of written informed consent
• Patient affiliated with Social Security

Exclusion criteria

• Existence of contraindication to taking amiloride:

• Known hypersensitivity to the molecule
• Hyperkalemia (potassium level (> 5.5 mmol / l))
• Use of another hyperkalemic diuretic or potassium salts
• Renal insufficiency (clearance <60 ml / min)
• Severe hepatocellular insufficiency
• In combination with lithium, converting enzyme inhibitors, angiotensin II inhibitors (except if there is hypokalemia), ciclosporin, tacrolimus, non-antiarrhythmic drugs giving torsades de pointes
• Cardiovascular and renal history, for subjects over 75 years old
• Patient, who from an investigator's point of view would not be compliant to the procedure of the study
• Pregnant or lactating patient
• Patient under trusteeship, under guardianship, protected by law