Skip to main content
OpenTrials
Completed

NCT Number: NCT01700712

Acid Production in Dental Plaque After Exposure to Probiotic Bacteria

The increasing interest in probiotic lactobacilli in health maintenance has raised the question of potential risks. One possible side effect could be an increased acidogenicity in dental plaque. The aim of this study was to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA) production in vitro and in vivo.

Methods. subjects (n=18) were given lozenges with probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for two weeks in a double-blinded, randomized cross-over trial. The concentration of LA in supragingival plaque samples was determined at baseline and after 2 weeks. Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with chair-side methods.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Caries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Copenhagen

Copenhagen, 2100, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • moderate to high counts of salivary mutans streptococci (>104 CFU) as estimated with the Dentocult SM chair-side test,
  • no visible open caries lesions or periodontal disease,

Exclusion criteria

  • smokers,
  • ingestion of probiotic bacteria within the last two months,
  • ingestion of antibiotics within the last two months

Treatment and study plan

Probiotic Lactobacilli reuteri

Dietary Supplement

Placebo

Dietary Supplement

Primary outcomes

  1. Acid production in plaque after exposure to probiotic bacteria

    Time frame: 2 weeks

Secondary outcomes

  1. Acid producton in plaque after in vitro exposure to probiotic bacteria

    Time frame: 1 hour

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • BioGaia AB
  • Calcin foundation, Denmark

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Oct 4, 2012
Registry last updated
Oct 4, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.