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Completed

NCT Number: NCT02315846

Acetylcholinesterase in Postoperative Delirium

The level of acetylcholinesterase is suspected to correlate with postoperative delirium. The investigators therefore score patients once preoperatively and twice postoperatively with the german version of the delirium-score NuDESC (Nursing Delirium Screening Scale) and compare the results with the acetylcholinesterase activity, butyrylcholinesterase activity and the serum anticholinergic activity (SAA) at corresponding time points.

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Key information

Conditions

Delirium Confusion Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Heidelberg

Heidelberg, 69120, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signed written informed consent
  • Elective surgery

Exclusion criteria

  • Preexisting psychiatric or neurological disease
  • No surgery
  • Reduced level of consciousness

Treatment and study plan

Primary outcomes

  1. change of acetylcholinesterase (U/l)

    Time frame: one day before surgery, 1-24h after surgery, 25-72h after surgery

    change of acetylcholinesterase in units per litre

Secondary outcomes

  1. change of NuDESC

    Time frame: one day before surgery, 1-24h after surgery, 25-72h after surgery

    change of nursing delirium screening score

  2. change of medication

    Time frame: one day before surgery, 1-24h after surgery, 25-72h after surgery

    change of medication, that could influence a delirium

  3. ICD-codes of main disease

    Time frame: 25-72h after surgery

    International classification of diseases-code of main disease

  4. ICD-codes of coexisting diseases

    Time frame: 25-72h after surgery

    International classification of diseases-codes of coexisting diseases

Sponsors and collaborators

Lead sponsor

Heidelberg University

Other

Registry information

Official study title

Role of Acetylcholinesterase for the Diagnosis of Postoperative Delirium in Patients Needing Postoperative Monitoring

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Dec 12, 2014
Registry last updated
May 17, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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