Accurate Prostate Cancer Following Using Low-Field MRI (Low-PRISM)

This study aims to compare the effectiveness of low-field MRI (0.55T) with traditional high-field MRI (3T) in prostate cancer screening and image quality improvement. The study is conducted in three phases: first, a pilot study with healthy volunteers to optimize the low-field MRI protocol; second, an evaluation of image quality between the two types of MRI in patients with metallic artifacts, particularly due to hip prostheses; and finally, the assessment of low-field MRI in patients with suspicious prostate lesions on high-field MRI (3T).

The goal is to find an accessible solution for prostate cancer screening while maintaining or improving image quality.

Inclusion criteria

Work Package1 (WP): 0.55T MRI Protocol Development

• Healthy male volunteers aged 18 and above.
• Agree to be contacted for incidental findings
• Signed informed consent

WP2: 0.55T Prostate MRI with patients with metallic implant(s)

• Adult men (≥18 y.o) with 3T MRI reported as sub-diagnostic due to metallic implants
• Signed informed Consent

WP3: 0.55T Prostate MRI with patients with suspicious lesion(s)

• Adult men (≥18 y.o)
• PI-RADS 4/5 lesions detected on 3T MRI, schedules for targeted biopsy
• Signed informed consent

Exclusion criteria

WP1: 0.55T MRI Protocol Development

• Individuals with a history of prostate cancer
• MR Contraindications as listed in the MR Safety Screening form

WP2: 0.55T Prostate MRI with patients with metallic implant(s)

• Contraindications as per MD instructions
• Any condition making the patient unsuitable for the study
• Refusal to be notified in case of incidental finding on the examination

WP3: 0.55T Prostate MRI with patients with suspicious lesion(s)

• Individuals with a history of prostate cancer.
• Contraindications as per MD instructions
• Any condition making the patient unsuitable for the study
• Refusal to be notified in case of incidental finding on the examination