Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.

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Key information

Conditions

Wheat Allergy Food Hypersensitivity Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Wheat Hypersensitivity

Age range

1 year–15 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pediatric department, Faculty of medicine Siriraj hospital, Mahidol university

Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

A patient with the age of 1-15 year old
A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion.
Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012

Exclusion criteria

First sign and symptom happens more than 4 hours since wheat ingestion
Have underlying disease such as heart disease, epilepsy etc.
Have contraindication for performed skin prick test

Treatment and study plan

Commercial extract and in-house wheat extract

Other

Patients with a history of wheat allergy underwent two skin test extracts, and open challenge with wheat. A blood test for specific IgE was performed in the same time.

Primary outcomes

correlation skin test result and food challenge result

Time frame: 3 year

Secondary outcomes

comparison of skin test result and specific IgE to challenge result

Time frame: 3 year

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2012
Study completion: 2012
First posted: Feb 18, 2010
Registry last updated: Feb 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed