Accuracy of FNAC in Thyroid Nodules Compared to to Surgical Specimen : QOC Experience

Thyroid gland diseases are the second most common endocrine disease following diabetes mellitus(1). Thyroid nodules are common disorders with a prevalence ranged from 4 to 7% in adult population, 5%-30% are malignant [1].Fine-needle aspiration cytology (FNAC) is an easy, cost-effective test for cancer diagnosis, and its use has markedly decreased the number of unnecessary thyroid surgeries(2).

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Key information

Conditions

Fine Needle Aspiration Cytology Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases Thyroid Neoplasms Thyroid Nodule

Age range

15 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Qena Oncology Center

Qina, +2, Egypt

About this study

it should be noted that FNAC cannot differentiate between benign and malignant follicular neoplasms.differentiation between follicular adenoma and follicular carcinoma is only possible after thyroid lobectomy.[2,3] In addition, a study of FNAC showed that 68% of the cases diagnosed by FNAC as follicular neoplasm turned out to be the follicular type of papillary carcinoma, indicting a considerable overlap between benign and malignant neoplasms.[4] Incidental findings of thyroid nodules have increased exponen¬tially in recent years, mostly due to the widespread application of high-resolution ultrasound (US) to the thyroid [5].Several in¬ternational scientific societies have established clinic-radiolog¬ical guidelines for the diagnosis and the management of thy¬roid nodules [2,3]. The American College of Radiology identifies 5 radiological risk levels and recommends US-guided fine-nee¬dle aspiration cytology (US-FNAC) of high-suspicion nodules if 10 mm or larger, and of nodules with a low risk for malignan¬cy only if larger than 25 mm [2]. According to the European Thyroid Association Guidelines (EU-TIRADS), nodules with no high-risk features (oval-shaped, isoechoic/hyperechoic with smooth margins) should be considered at low risk and FNA performed only if greater than 20 mm, while high-risk nodules greater than 10 mm should undergo FNAC, with possible FNAC also in 5-10 mm nodules if highly suspicious [3].

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Thyroid diseases
Multi nodullar
single nodules
diffuse goiter
Thyroid diseases underwent FNAC Then Thyroid surgery

Exclusion criteria

Patients with no diagnostic FNAC

Treatment and study plan

Fine Needle Aspiration Cytology

Procedure

Comparison between FNAC and post operative specimen after thyroid surgery

Other names: Thyrodectomy

Primary outcomes

Incidence of true positive results of FNAC after thyroidectomy

Time frame: 10 days

Accuracy of FNAC in thyroid nodules compared to to surgical specimen : QOC experience
Percentage of malignant thyroid nodules not observed by FNAC

Time frame: 10 days

type of thyroid malignancy not observed by FNAC
Incidence of false negative results by FNAC

Time frame: 10 days

false negative that diagnosed by FNAC not malignant but proved malignancy after surgical excion
Percentage of Total number of true results of FNAC to the total number of cases

Time frame: 10 days

accuracy of FNAC

Sponsors and collaborators

Lead sponsor

Qena Oncology Center

Other Gov

Registry information

Acronym: Thyroid FNAC

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2022
First posted: Aug 30, 2022
Registry last updated: Sep 26, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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