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Completed

NCT Number: NCT01329848

Accommodation Disorders

This project will develop clinically useful, objective measurements of accommodative insufficiency and fatigue using continuous autorefraction recordings. The development of these procedures will help vision care professionals diagnose and treat accommodative anomalies.

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Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Western University of Health Sciences

Pomona, California, 91766, United States

About this study

This project studies accommodative function, the ability to focus while doing near work. Visual discomfort symptoms, such as headaches, sore eyes, and blurred vision are commonly associated with prolonged reading or other near work. Researchers have long suspected accommodative dysfunction was involved but most clinical studies have failed to establish a relationship between weak accommodation and symptoms or reading impairments. Recent research, however, has found that clinical measure overestimate accommodative function and encourage the use of objective, autorefraction methods to measure and study accommodative weakness. This project will accomplish three goals. First, using autorefraction objective reliable procedures will be developed for measuring accommodative lag, the difference between the target location and where the eye is focused. Second, experiments will measure in real-time the impact of accommodative lag on reading fluency and visual discomfort systems. Third, studies will explore the role of the slow adaptive component in accommodative weakness. This work will lead to better methods for diagnosing and treating accommodative disorders.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • older adolescent and young adult
  • skilled readers who attend school
  • are skilled readers
  • have heavy reading demands

Exclusion criteria

  • Age > 30.
  • Abnormal vergence system.
  • Dry-eye.
  • Uncorrected visual defects or significant ocular pathology.
  • Learning disability or low IQ
  • Medical conditions that might cause uncomfortable visual symptoms (e.g., migraine headaches, epilepsy, head trauma); sensory defects (e.g., deafness), or neurological conditions (e.g., stuttering) that could impair reading development or oral reading fluency.
  • Somatosensory amplification.
  • Systemic illness or medication associated with accommodative dysfunction.

Treatment and study plan

Primary outcomes

  1. Accommodation Lag 5D

    Time frame: 3 week period

    Lag will be measured at different viewing distances and durations using autorefraction. Accommodation error refers to the difference between the distance where the target is located and where the eyes focus. Lag refers error that is under focussed; lead is error that is over focussed. This distance is measured in diopters, or 1/meter.

Secondary outcomes

  1. Conlon Symptom Survey

    Time frame: 3 weeks

    Measures visual discomfort symptoms while doing near work. 23 item survey using a 4-point rating scale (never, occasionally, often, almost always). Total raw score reported on a range from 0 to 69 with higher scores indicating more frequent symptoms.

Sponsors and collaborators

Lead sponsor

Western University of Health Sciences

Other

Collaborators

  • Southern California College of Optometry at Marshall B. Ketchum University

Registry information

Official study title

Using Accommodative Lag to Diagnose Accommodation Disorders

Acronym: AD

Important dates

Study start
2010
Primary completion
2012
Study completion
2013
First posted
Apr 6, 2011
Registry last updated
Jan 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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