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OpenTrials
Completed

NCT Number: NCT05671471

Accidental Reactions in Peanut/Tree Nut Allergic Children

Food allergy is an immune reaction, triggered by food protein allergens, of varying severity, from mild local reaction to life threatening anaphylaxis and fatalities.

Peanut is a plant from the botanical family of the Fabaceae, more commonly known as legumes. The prevalence of peanut and tree nut allergy is increasing. In France (ELFE cohort), it is estimated to 0.93%. The tree nuts include mainly almond, hazelnut, pistachio, cashew nut, walnut, pecan nut and Brazil nut. Allergy's prevalence is estimated to 0.54% in children up to 5.5 years. Peanut allergy is a main cause of anaphylaxis and deaths due to food allergy.

Recurrence of food allergy is a main concern. The risk has been estimated to 10% per year for peanut.

In France, Data in real-life on the rate of recurrence of allergic reactions and anaphylaxis to peanut/tree-nut as well as risk factors, are lacking.

The objective of this study is to assess the frequency of allergic reaction to peanut and tree-nuts, to describe the reactions' characteristics and risk factors.

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Key information

Conditions

Peanut and Tree Nut Allergy Anaphylaxis Food Hypersensitivity Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Nut Hypersensitivity Nut and Peanut Hypersensitivity Peanut Hypersensitivity

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hop Jeanne de Flandre Chu Lille

Lille, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Confirmed allergy to peanuts and/or nuts

Exclusion criteria

  • Other chronic diseases, except allergic comorbidities (asthma, rhinitis, atopic dermatitis, other food allergy)

Treatment and study plan

Primary outcomes

  1. the number of episode of allergic reactions in real life

    Time frame: At 1 year

Secondary outcomes

  1. the severity of the allergic reactions according to a validated scale (FASS scale)

    Time frame: At 1 year

  2. interview for the characteristics of the allergic reactions

    Time frame: At 1 year

    the characteristics of the reactions: symptoms, triggering food and quantity, location, emergency kit available, treatment administered, evolution (hospitalization or emergency room)

  3. interview to defined the risks factor associated

    Time frame: At 1 year

    risk factors for reaction:

    • Other known allergies
    • Asthma
    • Atopic dermatitis
    • Allergic rhinoconjunctivitis
    • Patient characteristics: sex, age

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Accidental Reactions in a French Cohort of Children With Peanut and/or Tree Nut Allergy.

Acronym: ALLERGY

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jan 4, 2023
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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