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Enrolling by Invitation

NCT Number: NCT07451574

Acceptability and Feasibility Study of Non-alcoholic Beverages

This project will elucidate the acceptability and feasibility of incorporating provision of non-alcoholic beers into alcohol use disorder treatment, for patients interested in using non-alcoholic beers as part of their recovery from alcohol use disorder.

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Key information

Conditions

Alcohol Use Disorder (AUD) Alcohol-Related Disorders Alcoholism Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

21 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stanford Prevention Research Center

Stanford, California, 94304, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants will be eligible if they report on the screening survey:

  • living in California and provide a California mailing address (to ship study materials to)
  • consuming ≤42 alcoholic beverages per week (as we seek to provide an equal count of the substitute beverage and budgetary restrictions prevent an amount greater than that)
  • having alcohol use disorder documented with ≥2 symptoms on the Alcohol Symptom Checklist
  • being enrolled in Ria Health treatment
  • having English language fluency

Exclusion criteria

  • Individuals will be excluded at the online screener survey stage if they do not meet all of the inclusion criteria.

Treatment and study plan

Non-alcoholic beer

Other

Participants will receive non-alcoholic beers and will be encouraged to consume the beverages to the extent they find useful/desirable during the 6-week study period.

Sparkling water

Other

Participants will receive sparkling water and will be encouraged to consume the beverages to the extent they find useful/desirable during the 6-week study period.

Primary outcomes

  1. Participant Beverage Satisfaction (Acceptability)

    Time frame: Assessed at the end of week 6

    "How satisfied were you with the beverages you received in this study?" with 5-pt scale response options ranging from "Very Unsatisfied" to "Very Satisfied." Higher scores [split by condition] will indicate greater acceptability.

  2. Participant Intention to Consume Assigned Beverage in the Future (Acceptability)

    Time frame: Assessed at the end of week 6

    "Do you intend to consume the beverage type you received in the future?" with 5-pt scale response options ranging from "Definitely not" to "Definitely." Higher scores [split by condition] will indicate greater acceptability.

  3. Participant Likelihood of Recommending Beverage (Acceptability)

    Time frame: Assessed at the end of week 6

    "Would you recommend the use of the beverage type you received for people who have alcohol use disorder?" with 5-pt scale response options ranging from "Definitely not" to "Definitely." Higher scores [split by condition] will indicate greater acceptability.

  4. Screened Out of Contacted (Feasibility)

    Time frame: Beginning of recruitment to end of recruitment (approximately 3-6 months)

    Percentage of participants who completed the screening measure out of those who were contacted. Higher percentage will indicate greater feasibility.

  5. Eligible Out of Screened (Feasibility)

    Time frame: Beginning of recruitment to end of recruitment (approximately 3-6 months)

    Percentage of participants who screen eligible out of those who were screened. Higher percentage will indicate greater feasibility.

  6. Enrolled Out of Eligible (Feasibility)

    Time frame: Beginning of recruitment to end of recruitment (approximately 3-6 months)

    Percentage of participants who enrolled out of those who screened eligible. Higher percentage will indicate greater feasibility.

  7. Retention (Feasibility)

    Time frame: Beginning of recruitment to end of data collection (approximately 3-6 months)

    Percentage of participants who completed the study out of those who enrolled. Higher percentage [split by condition] will indicate greater feasibility.

  8. Perception of Beverage Supply (Feasibility)

    Time frame: Assessed at the end of week 6

    Percentage of participants whose response to "How was the supply of beverages you received throughout the study?" is "just right" [as opposed to "too little" or "too much"]. Higher percentage [split by condition] will indicate greater feasibility.

Secondary outcomes

  1. Average Blood Alcohol Content Across 6 Weeks

    Time frame: Study weeks 1-6

    Average blood alcohol content (measured via breathalyzer) across the 6-week period split by condition.

  2. Change in Blood Alcohol Content Across 6 Weeks

    Time frame: Treatment entry to week 6

    Slopes of blood alcohol content separated by condition for: a) start of treatment to pre-study and b) during the 6-week study period [split by condition].

  3. Average Number of Days with Breathalyzer Readings

    Time frame: Assessed at 6 weeks.

    Average number of days with breathalyzer readings across the 6-week study.

  4. Median Number of Breathalyzer Readings Among Days with Readings

    Time frame: Assessed at 6 weeks.

    Median number of breathalyzer readings among days with readings across the 6-week study.

  5. Change in Reported Alcohol Use

    Time frame: Baseline to 6 weeks.

    Percentage of participants endorsing use of study-provided beverages who experienced (a) increase in alcohol use (defined as change in average use per week pre-study to average use per week across the study), (b) no change in alcohol use, (c) decrease in alcohol use [split by condition].

  6. Perceived Change in Craving

    Time frame: Assessed at 6 weeks.

    Percentage of participants endorsing use of study-provided beverages who reported (a) increased in desire to drink alcohol, (b) no change in desire to drink alcohol, (c) decreased desire to drink alcohol [split by condition] in response to the item "When I drink the study provided beverages I experience…Less desire to drink alcohol; No change in my desire to drink alcohol; or More desire to drink alcohol.

  7. Perceived Change in Alcohol Use

    Time frame: Assessed at 6 weeks.

    Percentage of participants endorsing use of study-provided beverages who reported (a) increased in alcohol use, (b) no change in alcohol use, (c) increased alcohol use [split by condition] in response to the item "Because I drink the study provided beverages I drink...Less alcohol than I otherwise would; The same amount of alcohol that I otherwise would; or More alcohol than I otherwise would."

  8. Perceived Impact of Beverages on Recovery

    Time frame: Assessed at 6 weeks.

    Percentage of participants who responded to the item "What impact did the study provided beverages have on your recovery from alcohol use disorder?" with (a) Harmful; (b) No impact; or (c) Helpful [split by condition].

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Official study title

Non-alcoholic Beverages as a Therapeutic Adjunct in Alcohol Use Disorder Treatment: a Pilot Study of Acceptability and Feasibility

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 5, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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